Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones

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Title: Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones
Authors: Azuaje, Jhonny | Pérez-Rubio, José M. | Yaziji, Vicente | El Maatougui, Abdelaziz | Gonzalez-Gomez, Jose C. | Sánchez-Pedregal, Vı́ctor M. | Navarro-Vázquez, Armando | Masaguer, Christian F. | Teijeira, Marta | Sotelo, Eddy
Research Group/s: Catálisis Estereoselectiva en Síntesis Orgánica (CESO)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: 1,4-benzodiazepin-2-ones | Functionally | Skeletally | Stereochemically diverse | Ugi-based assembly
Knowledge Area: Química Orgánica
Issue Date: 5-Jan-2015
Publisher: American Chemical Society
Citation: The Journal of Organic Chemistry. 2015, 80(3): 1533-1549. doi:10.1021/jo502382q
Abstract: A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described. By virtue of its convergence, atom economy, and bond-forming efficiency, the methodology documented herein exemplifies the reconciliation of structural complexity and experimental simplicity in the context of medicinal chemistry projects.
Sponsor: This work was financially supported by the Galician Government (Spain), Projects: 09CSA016234PR and GPC-2014-PG037. J.A. thanks FUNDAYACUCHO (Venezuela) for a predoctoral grant and Deputación da Coruña (Spain) for a postdoctoral research grant. A.N.-V. thanks the Spanish government for a Ramón y Cajal research contract.
ISSN: 0022-3263 (Print) | 1520-6904 (Online)
DOI: 10.1021/jo502382q
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2015 American Chemical Society
Peer Review: si
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Appears in Collections:INV - CESO - Artículos de Revistas

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