Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10045/52883
| Title: | Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones |
|---|---|
| Authors: | Azuaje, Jhonny | Pérez-Rubio, José M. | Yaziji, Vicente | El Maatougui, Abdelaziz | Gonzalez-Gomez, Jose C. | Sánchez-Pedregal, Vı́ctor M. | Navarro-Vázquez, Armando | Masaguer, Christian F. | Teijeira, Marta | Sotelo, Eddy |
| Research Group/s: | Catálisis Estereoselectiva en Síntesis Orgánica (CESO) |
| Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
| Keywords: | 1,4-benzodiazepin-2-ones | Functionally | Skeletally | Stereochemically diverse | Ugi-based assembly |
| Knowledge Area: | Química Orgánica |
| Issue Date: | 5-Jan-2015 |
| Publisher: | American Chemical Society |
| Citation: | The Journal of Organic Chemistry. 2015, 80(3): 1533-1549. doi:10.1021/jo502382q |
| Abstract: | A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described. By virtue of its convergence, atom economy, and bond-forming efficiency, the methodology documented herein exemplifies the reconciliation of structural complexity and experimental simplicity in the context of medicinal chemistry projects. |
| Sponsor: | This work was financially supported by the Galician Government (Spain), Projects: 09CSA016234PR and GPC-2014-PG037. J.A. thanks FUNDAYACUCHO (Venezuela) for a predoctoral grant and Deputación da Coruña (Spain) for a postdoctoral research grant. A.N.-V. thanks the Spanish government for a Ramón y Cajal research contract. |
| URI: | http://hdl.handle.net/10045/52883 |
| ISSN: | 0022-3263 (Print) | 1520-6904 (Online) |
| DOI: | 10.1021/jo502382q |
| Language: | eng |
| Type: | info:eu-repo/semantics/article |
| Rights: | © 2015 American Chemical Society |
| Peer Review: | si |
| Publisher version: | http://dx.doi.org/10.1021/jo502382q |
| Appears in Collections: | INV - CESO - Artículos de Revistas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
 2015_Azuaje_etal_JOC_final.pdf | Versión final (acceso restringido) | 2,85 MB | Adobe PDF | Open Request a copy |
 2015_Azuaje_etal_JOC_rev.pdf | Versión revisada (acceso abierto) | 1,38 MB | Adobe PDF | Open Preview |
See citations in Google Scholar
Items in RUA are protected by copyright, with all rights reserved, unless otherwise indicated.