1-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1-one
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Título: | 1-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1-one |
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Autor/es: | Nacher-Luis, Anna | Pastor, Isidro M. |
Grupo/s de investigación o GITE: | Alternative Methodologies In Chemistry (AMIC) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Palabras clave: | N-heterocycle | Chalcone | 1,4-addition | Catalysis | Organic synthesis |
Fecha de publicación: | 12-mar-2024 |
Editor: | MDPI |
Cita bibliográfica: | Molbank. 2024, 2024(1): M1791. https://doi.org/10.3390/M1791 |
Resumen: | The study of new catalytic protocols for the synthesis of organic compounds with a more sustainable perspective is of interest. The use of ionic organic solids, such as 1,3-bis(carboxymethyl)imidazolium chloride as a catalyst has allowed the Michael addition of N-heterocycles to chalcones. This methodology has been applied to the unique preparation of the potential bioactive compound 1-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1-one with moderate yield, due to the retro-Michael reaction. Both synthetic reactions (i.e., preparation of chalcone and triazole Michael-addition to chalcone) have good green metrics. |
Patrocinador/es: | This research was funded by Ministerio de Ciencia e Innovación (grant number PID2021-127332NB-I00), and the University of Alicante (grant numbers VIGROB-316, UASTI22-23, UADIF22-104). |
URI: | http://hdl.handle.net/10045/141507 |
ISSN: | 1422-8599 |
DOI: | 10.3390/M1791 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/M1791 |
Aparece en las colecciones: | INV - AMIC - Artículos de Revistas |
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