Impact of Heavy Metals on Human Male Fertility—An Overview
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Título: | Impact of Heavy Metals on Human Male Fertility—An Overview |
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Autor/es: | López-Botella, Andrea | Velasco-Ruiz, Irene | Acién, Maribel | Sáez Espinosa, Paula | Todolí Torró, José Luis | Sánchez, Raquel | Gómez-Torres, María José |
Grupo/s de investigación o GITE: | Grupo de Inmunología, Biología Celular y del Desarrollo | Análisis de Polímeros y Nanomateriales |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Biotecnología | Universidad de Alicante. Departamento de Química Analítica, Nutrición y Bromatología |
Palabras clave: | Endocrine disrupting compounds | Environmental exposure | Heavy metals | Human sperm | Male fertility | Occupational exposure |
Área/s de conocimiento: | Biología Celular | Química Analítica |
Fecha de publicación: | 15-sep-2021 |
Editor: | MDPI |
Cita bibliográfica: | López-Botella A, Velasco I, Acién M, Sáez-Espinosa P, Todolí-Torró J-L, Sánchez-Romero R, Gómez-Torres MJ. Impact of Heavy Metals on Human Male Fertility—An Overview. Antioxidants. 2021; 10(9):1473. https://doi.org/10.3390/antiox10091473 |
Resumen: | Heavy metals are endocrine disruptors which interfere with processes mediated by endogenous hormones of the organism, negatively affecting endocrine functions. Some studies have correlated heavy metal exposure with male infertility. However, the number of studies conducted on humans are limited. Therefore, the aim of this study is to summarize the current knowledge on how heavy metals influence human male fertility. Hence, three distinct databases were consulted—PubMed, Scopus and Web of Science—using single keywords and combinations of them. The total number of identified articles was 636. Nevertheless, by using the inclusion and exclusion criteria, 144 articles were finally included in this work. Results display that the development of adequate instruments for heavy metal assessment may play an important function in human male fertility diagnosis and treatment. Furthermore, clinical trials could be useful to confirm the role of heavy metals in human male fertility diagnosis. Overall, further research is required to fully understand the molecular and cellular basis of the influence of environmental and occupational exposure to heavy metals on human male infertility and reproductive outcomes. |
Patrocinador/es: | This study was funded by Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (UGP-19-042 and UGP-20-039). |
URI: | http://hdl.handle.net/10045/117871 |
ISSN: | 2076-3921 |
DOI: | 10.3390/antiox10091473 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/antiox10091473 |
Aparece en las colecciones: | INV - Grupo de Inmunología - Artículos de Revistas INV - NANOBIOPOL - Artículos de Revistas |
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