Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10045/114287
| Title: | Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats |
|---|---|
| Authors: | Snezhkova, Elisaveta | Rodionova, Natalia | Bilko, Dennis | Silvestre-Albero, Joaquín | Sydorenko, Alexey | Yurchenko, Olga | Pakharenko, Marharyta | Alavijeh, Mo | Bardakhivska, Kvitoslava | Riabchenko, Natalia | Nikolaev, Vladimir |
| Research Group/s: | Materiales Avanzados |
| Center, Department or Service: | Universidad de Alicante. Departamento de Química Inorgánica | Universidad de Alicante. Instituto Universitario de Materiales |
| Keywords: | Activated charcoal | Enterosorbent | Acute radiation sickness | Rats |
| Knowledge Area: | Química Inorgánica |
| Issue Date: | 2-Apr-2021 |
| Publisher: | MDPI |
| Citation: | Snezhkova E, Rodionova N, Bilko D, Silvestre-Albero J, Sydorenko A, Yurchenko O, Pakharenko M, Alavijeh M, Bardakhivska K, Riabchenko N, Nikolaev V. Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats. Applied Sciences. 2021; 11(7):3174. https://doi.org/10.3390/app11073174 |
| Abstract: | Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment. |
| Sponsor: | This research was funded by H2020-MSCA-RISE-2016 project, grant number 734641 acronym NanoMed. |
| URI: | http://hdl.handle.net/10045/114287 |
| ISSN: | 2076-3417 |
| DOI: | 10.3390/app11073174 |
| Language: | eng |
| Type: | info:eu-repo/semantics/article |
| Rights: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Peer Review: | si |
| Publisher version: | https://doi.org/10.3390/app11073174 |
| Appears in Collections: | INV - LMA - Artículos de Revistas Research funded by the EU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
 Snezhkova_etal_2021_ApplSci.pdf | 3,27 MB | Adobe PDF | Open Preview | |
See citations in Google Scholar
This item is licensed under a Creative Commons License
