Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats
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http://hdl.handle.net/10045/114287
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Campo DC | Valor | Idioma |
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dc.contributor | Materiales Avanzados | es_ES |
dc.contributor.author | Snezhkova, Elisaveta | - |
dc.contributor.author | Rodionova, Natalia | - |
dc.contributor.author | Bilko, Dennis | - |
dc.contributor.author | Silvestre-Albero, Joaquín | - |
dc.contributor.author | Sydorenko, Alexey | - |
dc.contributor.author | Yurchenko, Olga | - |
dc.contributor.author | Pakharenko, Marharyta | - |
dc.contributor.author | Alavijeh, Mo | - |
dc.contributor.author | Bardakhivska, Kvitoslava | - |
dc.contributor.author | Riabchenko, Natalia | - |
dc.contributor.author | Nikolaev, Vladimir | - |
dc.contributor.other | Universidad de Alicante. Departamento de Química Inorgánica | es_ES |
dc.contributor.other | Universidad de Alicante. Instituto Universitario de Materiales | es_ES |
dc.date.accessioned | 2021-04-20T16:43:47Z | - |
dc.date.available | 2021-04-20T16:43:47Z | - |
dc.date.issued | 2021-04-02 | - |
dc.identifier.citation | Snezhkova E, Rodionova N, Bilko D, Silvestre-Albero J, Sydorenko A, Yurchenko O, Pakharenko M, Alavijeh M, Bardakhivska K, Riabchenko N, Nikolaev V. Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats. Applied Sciences. 2021; 11(7):3174. https://doi.org/10.3390/app11073174 | es_ES |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | http://hdl.handle.net/10045/114287 | - |
dc.description.abstract | Activated charcoal (AC) can be taken orally as enterosorbent for treatment of pathological states related to exogenous and endogenous intoxications. Synthesized granulated AC with a highly developed active surface (SBET ~2700 m2/g) was used as a medical countermeasure (MCM) to acute radiation sickness (ARS) in rats after total body X-ray irradiation. AC demonstrates positive results in ARS treatment, as expressed in, (i) a decrease in body weight loss, (ii) a protection of bone marrow (BM) cells colony formation capacity, (iii) a reduction of BM chromosomal aberrations and small intestine and spleen tissue damage, (iv) an amelioration of white blood cell count, and (v) a mitigation of superoxide ion generation rate in the liver. AC oral prescription seems to be perspective modality of ARS treatment. | es_ES |
dc.description.sponsorship | This research was funded by H2020-MSCA-RISE-2016 project, grant number 734641 acronym NanoMed. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.subject | Activated charcoal | es_ES |
dc.subject | Enterosorbent | es_ES |
dc.subject | Acute radiation sickness | es_ES |
dc.subject | Rats | es_ES |
dc.subject.other | Química Inorgánica | es_ES |
dc.title | Orally Administered Activated Charcoal as a Medical Countermeasure for Acute Radiation Syndrome in Rats | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.peerreviewed | si | es_ES |
dc.identifier.doi | 10.3390/app11073174 | - |
dc.relation.publisherversion | https://doi.org/10.3390/app11073174 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/734641 | es_ES |
Aparece en las colecciones: | INV - LMA - Artículos de Revistas Investigaciones financiadas por la UE |
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Snezhkova_etal_2021_ApplSci.pdf | 3,27 MB | Adobe PDF | Abrir Vista previa | |
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