DNA catabolites in triathletes: effects of supplementation with an aronia–citrus juice (polyphenols-rich juice)
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Título: | DNA catabolites in triathletes: effects of supplementation with an aronia–citrus juice (polyphenols-rich juice) |
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Autor/es: | García-Flores, Libia Alejandra | Medina, Sonia | Cejuela, Roberto | Martínez Sanz, José Miguel | Abellán, Ángel | Genieser, Hans-Gottfried | Ferreres, Federico | Gil-Izquierdo, Ángel |
Grupo/s de investigación o GITE: | Grupo de Investigación en Ciencias de la Actividad Física y el Deporte (GICAFD) | Grupo de Investigación en Alimentación y Nutrición (ALINUT) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas | Universidad de Alicante. Departamento de Enfermería |
Palabras clave: | Oxidative stress | DNA catabolites | Physical exercise | Juice intake | Citrus and Aronia melanocarpa |
Área/s de conocimiento: | Educación Física y Deportiva | Enfermería |
Fecha de publicación: | 17-mar-2016 |
Editor: | Royal Society of Chemistry |
Cita bibliográfica: | Food & Function. 2016, 7: 2084-2093. doi:10.1039/c6fo00252h |
Resumen: | In this study we analyzed whether our aronia–citrus juice (ACJ, the composition is based on a mixture of 95% citrus juice with 5% of Aronia melanocarpa juice), rich in polyphenols, and physical exercise had an effect on seven catabolites of DNA identified in plasma and on a urine isoprostane (8-iso-PGF2α). Sixteen elite triathletes on a controlled diet for triathlon training (45 days) were used in this clinical trial. Our results show a decrease in the 8-hydroxy-2′-deoxyguanosine concentration due to chronic physical exercise. The ACJ intake and physical exercise maintained the guanosine-3′,5′-cyclic monophosphate plasmatic concentrations and decreased the concentration of 8-hydroxyguanine as well as urinary values of 8-iso-PGF2α. Finally, we observed a significant increase in the 8-nitroguanosine levels in triathletes after ACJ intake, compared to the placebo stage. It is concluded that the combination of the intake of ACJ, rich in polyphenolic compounds, with adequate training was able to influence the plasmatic and urinary values of oxidative stress biomarkers. This suggests a positive effect on the oxidative damage and potential associations with DNA repair mechanisms. |
Patrocinador/es: | LAGF was awarded a pre-doctoral FPI fellowship (BES2012-060185) by the Spanish government. This study was supported by the project AGL2011-23690 (CICYT) (Spanish Ministry of Economy and Competitiveness). This work has been partially funded by the “Fundación Séneca de la Región de Murcia” Grupo de Excelencia 19900/GERM/15. |
URI: | http://hdl.handle.net/10045/54330 |
ISSN: | 2042-6496 (Print) | 2042-650X (Online) |
DOI: | 10.1039/c6fo00252h |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © Royal Society of Chemistry 2016 |
Revisión científica: | si |
Versión del editor: | http://dx.doi.org/10.1039/c6fo00252h |
Aparece en las colecciones: | INV - GICAFD - Artículos de Revistas INV - ALINUT - Artículos de Revistas INV - SCAPE - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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2016_Garcia-Flores_etal_FoodFunct_final.pdf | Versión final (acceso restringido) | 474,8 kB | Adobe PDF | Abrir Solicitar una copia |
2016_Garcia-Flores_etal_FoodFunct_accepted.pdf | Accepted Manuscript (acceso abierto) | 1,07 MB | Adobe PDF | Abrir Vista previa |
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