Ionization of biomolecular targets by ion impact: input data for radiobiological applications

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Title: Ionization of biomolecular targets by ion impact: input data for radiobiological applications
Authors: Vera Gomis, Pablo de | Abril, Isabel | García Molina, Rafael | Solov'yov, Andrey V.
Research Group/s: Interacción de Partículas Cargadas con la Materia
Center, Department or Service: Universidad de Alicante. Departamento de Física Aplicada
Keywords: Effects of ionizing radiation on biological systems | Proteins | Dosimetry/exposure assessment | Diseases | Reactions in complex biological systems | Nucleic acids
Knowledge Area: Física Aplicada
Issue Date: 2013
Publisher: IOP Publishing
Citation: Journal of Physics: Conference Series. 2013, 438: 012015. doi:10.1088/1742-6596/438/1/012015
Abstract: In this work we review and further develop a semiempirical model recently proposed for the ion impact ionization of complex biological media. The model is based on the dielectric formalism, and makes use of a semiempirical parametrization of the optical energy-loss function of bioorganic compounds, allowing the calculation of single and total ionization cross sections and related quantities for condensed biological targets, such as liquid water, DNA and its components, proteins, lipids, carbohydrates or cell constituents. The model shows a very good agreement with experimental data for water, adenine and uracil, and allows the comparison of the ionization efficiency of different biological targets, and also the average kinetic energy of the ejected secondary electrons.
Sponsor: Financial support from the Spanish Ministerio de Economía y Competitividad and the European Regional Development Fund within the Project FIS2010–17225 and from the Conselleria d’Educació, Cultura i Esport de la Generalitat Valenciana for granting PdV within the VALi+d program. Support from the COST Action MP1002 NanoIBCT is greatfully acknowledged.
URI: http://hdl.handle.net/10045/35826
ISSN: 1742-6588 (Print) | 1742-6596 (Online)
DOI: 10.1088/1742-6596/438/1/012015
Language: eng
Type: info:eu-repo/semantics/article
Rights: Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Published under licence by IOP Publishing Ltd
Peer Review: si
Publisher version: http://dx.doi.org/10.1088/1742-6596/438/1/012015
Appears in Collections:INV - IPCM - Artículos de Revistas

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