Metal–Organic Frameworks as Drug Delivery Platforms for Ocular Therapeutics
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http://hdl.handle.net/10045/86928
Title: | Metal–Organic Frameworks as Drug Delivery Platforms for Ocular Therapeutics |
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Authors: | Gandara-Loe, Jesús | Ortuño-Lizarán, Isabel | Fernández-Sánchez, Laura | Alió, Jorge L. | Cuenca, Nicolás | Vega Estrada, Alfredo | Silvestre-Albero, Joaquín |
Research Group/s: | Materiales Avanzados | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) |
Center, Department or Service: | Universidad de Alicante. Departamento de Química Inorgánica | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía | Universidad de Alicante. Instituto Universitario de Materiales |
Keywords: | MOFs | Amorphization | Glaucoma treatment | Drug delivery | Ocular therapeutics |
Knowledge Area: | Química Inorgánica | Fisiología | Farmacología | Biología Celular |
Issue Date: | 18-Dec-2018 |
Publisher: | American Chemical Society |
Citation: | ACS Applied Materials & Interfaces. 2019, 11(2): 1924-1931. doi:10.1021/acsami.8b20222 |
Abstract: | Metal–organic frameworks (MOFs) have been evaluated as potential nanocarriers for intraocular incorporation of brimonidine tartrate to treat chronic glaucoma. Experimental results show that UiO-67 and MIL-100 (Fe) exhibit the highest loading capacity with values up to 50–60 wt %, whereas the performance is quite limited for MOFs with narrow cavities (below 0.8 nm, for example, UiO-66 and HKUST-1). The large loading capacity in UiO-67 is accompanied by an irreversible structural amorphization in aqueous and physiological media that promotes extended release kinetics above 12 days. Compared to the traditional drawbacks associated with the sudden release of the commercial drugs (e.g., ALPHAGAN), these results anticipate UiO-67 as a potential nanocarrier for drug delivery in intraocular therapeutics. These promising results are further supported by cytotoxicity tests using retinal photoreceptor cells (661W). Toxicity of these structures (including the metal nodes and organic ligands) for retinal cells is rather low for all samples evaluated, except for HKUST-1. |
Sponsor: | Authors would like to acknowledge the financial support from MINECO (MAT2016-80285-p), GV (PROMETEOII/2014/004), and H2020 (MSCA-RISE-2016/NanoMed Project). J.G.-L. acknowledges GV (GRISOLIAP/2016/089) for the research contract. N.C. acknowledges the financial support from MINECO (MINECO-FEDER-BFU2015-67139-R), ISCIII (RETICS-FEDER RD16/0008/0016), and GV (Prometeo 2016/158). I.O.-L. acknowledges Ministerio de Educación, Spain (FPU 14/03166). |
URI: | http://hdl.handle.net/10045/86928 |
ISSN: | 1944-8244 (Print) | 1944-8252 (Online) |
DOI: | 10.1021/acsami.8b20222 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © 2018 American Chemical Society |
Peer Review: | si |
Publisher version: | https://doi.org/10.1021/acsami.8b20222 |
Appears in Collections: | Research funded by the EU INV - NEUROVIS - Artículos de Revistas INV - LMA - Artículos de Revistas |
Files in This Item:
File | Description | Size | Format | |
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2019_Gandara-Loe_etal_ACSApplMaterInterfaces_final.pdf | Versión final (acceso restringido) | 935,54 kB | Adobe PDF | Open Request a copy |
2019_Gandara-Loe_etal_ACSApplMaterInterfaces_accepted.pdf | Accepted Manuscript (acceso abierto) | 312,58 kB | Adobe PDF | Open Preview |
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