Lipidomic approach in young adult triathletes: effect of supplementation with a polyphenols-rich juice on neuroprostane and F2-dihomo-isoprostane markers

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Title: Lipidomic approach in young adult triathletes: effect of supplementation with a polyphenols-rich juice on neuroprostane and F2-dihomo-isoprostane markers
Authors: García-Flores, Libia Alejandra | Medina, Sonia | Oger, Camille | Galano, Jean-Marie | Durand, Thierry | Cejuela Anta, Roberto | Martínez Sanz, José Miguel | Ferreres, Federico | Gil-Izquierdo, Ángel
Research Group/s: Research in Physical Education, Fitness and Performance (RIPEFAP) | Grupo de Investigación en Alimentación y Nutrición (ALINUT)
Center, Department or Service: Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas | Universidad de Alicante. Departamento de Enfermería
Keywords: Polyphenols | Oxidative stress | F4-neuroprostanes | F2-dihomo-isoprostanes | Aronia-Citrus Juice | Athletes | Biomarkers
Knowledge Area: Educación Física y Deportiva | Enfermería
Issue Date: 30-Aug-2016
Publisher: Royal Society of Chemistry
Citation: Food & Function. 2016, 7: 4343-4355. doi:10.1039/C6FO01000H
Abstract: The aim of the this study was to determine the effect of a polyphenols-rich juice (aronia-citrus juice, ACJ) on F4-neuroprostanes and F2-dihomo-isoprostanes—markers of oxidative stress associated with the central nervous system (CNS)—in 16 elite triathletes under a controlled diet for triathlon training (145 days). In the triathletes, a decrease of the lipid peroxidation markers after ACJ intake, associated with neuronal membrane degradation (10-epi-10-F4t-neuroprostane and 10-F4t-neuroprostane), was observed when compared with placebo stage values. Regarding the F2-dihomo-isoprostanes, a significant decrease of the neuromotor system damage biomarkers (17-F2t-dihomo-isoprostane) with an increase of training load during the study was observed, although the decrease of the load training at the last stage showed a significant increase of the values of ent-7-(RS)-7-F2t-dihomo-IsoP, suggesting a possible role in adaptation post-training. On the other hand, the changes in the excretion of 17-epi-17-F2t-dihomo-IsoP provided a positive connection between physical exercise and ACJ intake. Thus, the results showed in this clinical study in young triathletes will help to elucidate novel interactions and mechanisms between the excretion of lipid peroxidation metabolites from CNS, supplementation of polyphenols-rich juice in the diet and physical exercise during a training season.
Sponsor: This study was supported by the project AGL2011-23690 (CICYT) (Spanish Ministry of Economy and Competitiveness). This work has been partially funded by the “Fundación Séneca de la Región de Murcia” Grupo de Excelencia 19900/GERM/15. LAGF was granted a pre-doctoral FPI fellowship (BES2012-060185) by the Spanish government.
ISSN: 2042-6496 (Print) | 2042-650X (Online)
DOI: 10.1039/C6FO01000H
Language: eng
Type: info:eu-repo/semantics/article
Rights: © The Royal Society of Chemistry 2016
Peer Review: si
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Appears in Collections:INV - ALINUT - Artículos de Revistas
INV - RIPEFAP - Artículos de Revistas

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