Assessment oxidative stress biomarkers –neuroprostanes and dihomo-isoprostanes- in elite triathletes urine after two weeks of moderate altitude training
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor | Grupo de Investigación en Ciencias de la Actividad Física y el Deporte (GICAFD) | es |
dc.contributor | Grupo de Investigación en Alimentación y Nutrición (ALINUT) | es |
dc.contributor.author | García-Flores, Libia Alejandra | - |
dc.contributor.author | Medina, Sonia | - |
dc.contributor.author | Cejuela, Roberto | - |
dc.contributor.author | Martínez Sanz, José Miguel | - |
dc.contributor.author | Oger, Camille | - |
dc.contributor.author | Galano, Jean-Marie | - |
dc.contributor.author | Durand, Thierry | - |
dc.contributor.author | Casas-Pina, Teresa | - |
dc.contributor.author | Martínez-Hernández, Pedro | - |
dc.contributor.author | Ferreres, Federico | - |
dc.contributor.author | Gil-Izquierdo, Ángel | - |
dc.contributor.other | Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas | es |
dc.contributor.other | Universidad de Alicante. Departamento de Enfermería | es |
dc.date.accessioned | 2016-02-24T10:12:25Z | - |
dc.date.available | 2016-02-24T10:12:25Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Free Radical Research. 2015. doi:10.3109/10715762.2015.1111514 | es |
dc.identifier.issn | 1071-5762 (Print) | - |
dc.identifier.issn | 1029-2470 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/53376 | - |
dc.description.abstract | This randomized and controlled trial investigated whether the increase in elite training at different altitudes altered the oxidative stress biomarkers of the nervous system. This is the first study to investigate four F4-neuroprostanes and four F2-dihomo-isoprostanes quantified in 24-hour urine. The quantification was carried out by Ultra High Pressure Liquid Chromatography-triple Quadrupole-Tandem Mass Spectrometry (UHPLC-QqQ-MS/MS). Sixteen elite triathletes agreed to participate in the project. They were randomized in two groups, a group submitted to Altitude Training (n=8) and a group submitted to Sea Level Training (n=8), with a Control group of non-athletes (n=8). After experimental period, the Altitude Training group triathletes gave significant data: 17-epi-17-F2t-dihomo-IsoP (from 5.2 ± 1.4 µg/mL 24 h-1 to 6.6 ± 0.6 µg/mL 24 h-1), ent-7(RS)-7-F2t-dihomo-IsoP (from 6.6 ± 1.7 µg/mL 24 h-1 to 8.6 ± 0.9 µg /mL 24 h-1), and ent-7-epi-7-F2t-dihomo-IsoP (from 8.4 ± 2.2 µg/mL 24 h-1 to 11.3 ± 1.8 µg/mL 24 h-1) increased, while, of the neuronal degeneration-related compounds, only 10-epi-10-F4t-NeuroP (8.4 ± 1.7 µg/mL 24 h-1) and 10-F4t-NeuroP (5.2 ± 2.9 µg/mL 24 h-1) were detected in this group. For the control group and sea level training groups, no significant changes had occurred at the end of the 2-weeks experimental period. Therefore, and as the main conclusion, the training at moderate altitude increased the F4-NeuroPs- and F2-dihomo-isoPs-related oxidative damage of the central nervous system (CNS) compared to similar training at sea level. | es |
dc.description.sponsorship | This study was supported by the project AGL2011-23690 (CICYT) (Spanish Ministry of Economy and Competitiveness). LAGF was granted with a pre-doctoral FPI fellowship BES2012-060185 by the Spanish government. The authors are also grateful to the University of Alicante for its collaboration. Sonia Medina was appointed under a research contract from the project AGL2011-23690 (CICYT). | es |
dc.language | eng | es |
dc.publisher | Taylor & Francis | es |
dc.rights | © 2015 Taylor & Francis | es |
dc.subject | Neuroprostanes | es |
dc.subject | Dihomo-isoprostanes | es |
dc.subject | Oxidative stress | es |
dc.subject | Altitude | es |
dc.subject | Physical exercise | es |
dc.subject | UHPLC-QqQ-MS/MS | es |
dc.subject.other | Educación Física y Deportiva | es |
dc.subject.other | Enfermería | es |
dc.title | Assessment oxidative stress biomarkers –neuroprostanes and dihomo-isoprostanes- in elite triathletes urine after two weeks of moderate altitude training | es |
dc.type | info:eu-repo/semantics/article | es |
dc.peerreviewed | si | es |
dc.identifier.doi | 10.3109/10715762.2015.1111514 | - |
dc.relation.publisherversion | http://dx.doi.org/10.3109/10715762.2015.1111514 | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
Aparece en las colecciones: | INV - ALINUT - Artículos de Revistas INV - GICAFD - Artículos de Revistas INV - SCAPE - Artículos de Revistas |
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2015_Garcia-Flores_etal_FreeRadicalRes_accepted.pdf | Accepted Manuscript (acceso abierto) | 672,27 kB | Adobe PDF | Abrir Vista previa |
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