Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats

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Title: Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats
Authors: Fernández Sánchez, Laura | Lax, Pedro | Esquiva Sobrino, Gema | Martín-Nieto, José | Pinilla Lozano, Isabel | Cuenca, Nicolás
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) | Genética Humana y de Mamíferos (GHM)
Center, Department or Service: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología
Keywords: Saffron | Safranal | Retinal degeneration | Retinitis pigmentosa | Photoreceptor
Knowledge Area: Biología Celular | Fisiología | Genética
Issue Date: 10-Aug-2012
Publisher: Public Library of Science (PLoS)
Citation: FERNÁNDEZ-SÁNCHEZ, Laura, et al. “Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats”. PLoS ONE 7(8): e43074. doi:10.1371/journal.pone.0043074
Abstract: Saffron, an extract from Crocus sativus, has been largely used in traditional medicine for its antiapoptotic and anticarcinogenic properties. In this work, we investigate the effects of safranal, a component of saffron stigmas, in attenuating retinal degeneration in the P23H rat model of autosomal dominant retinitis pigmentosa. We demonstrate that administration of safranal to homozygous P23H line-3 rats preserves both photoreceptor morphology and number. Electroretinographic recordings showed higher a- and b-wave amplitudes under both photopic and scotopic conditions in safranal-treated versus non-treated animals. Furthermore, the capillary network in safranal-treated animals was preserved, unlike that found in untreated animals. Our findings indicate that dietary supplementation with safranal slows photoreceptor cell degeneration and ameliorates the loss of retinal function and vascular network disruption in P23H rats. This work also suggests that safranal could be potentially useful to retard retinal degeneration in patients with retinitis pigmentosa.
Sponsor: This research was supported by grants from the Spanish Government (BFU2009-07793/BFI and RETICS RD07/0062/0012), Organización Nacional de Ciegos de España (ONCE), Fundación Lucha contra la Ceguera (FUNDALUCE) and Fundación Médica Mutua Madrileña.
URI: http://hdl.handle.net/10045/25073
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0043074
Language: eng
Type: info:eu-repo/semantics/article
Rights: © Fernández-Sánchez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Peer Review: si
Publisher version: http://dx.doi.org/10.1371/journal.pone.0043074
Appears in Collections:INV - GHM - Artículos de Revistas
INV - NEUROVIS - Artículos de Revistas

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