Does stress response axis activation differ between patients with autoimmune disease and healthy people?

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Title: Does stress response axis activation differ between patients with autoimmune disease and healthy people?
Authors: Montero-López, Eva | Peralta-Ramírez, María Isabel | Ortego-Centeno, Norberto | Sabio, José Mario | Callejas-Rubio, José Luis | Navarrete-Navarrete, Nuria | García-Ríos, M. Carmen | Santos-Ruiz, Ana
Research Group/s: Calidad de Vida, Bienestar Psicológico y Salud | Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE)
Center, Department or Service: Universidad de Alicante. Departamento de Psicología de la Salud
Keywords: Cortisol | HPA axis | Sjögren's syndrome | Stress | Systemic lupus erythematosus | Systemic sclerosis
Issue Date: 7-Mar-2024
Publisher: John Wiley & Sons
Citation: Stress and Health. 2024. https://doi.org/10.1002/smi.3392
Abstract: Many studies have shown that patients with autoimmune disease present a hypoactive hypothalamic-pituitary-adrenal (HPA) axis, but the results are controversial. Our objective was to study differences in stress response axis activity between patients with autoimmune disease and healthy people. The study sample consisted of 97 women divided into four groups: 37 healthy women (HW), 21 with systemic lupus erythematosus (SLE), 21 with Sjögren's syndrome (SS), and 18 with systemic sclerosis (SSc). After being exposed to a stress task, participants' skin conductance and salivary cortisol levels were measured in order to assess their response to psychological stress. Diurnal cortisol concentrations were assessed by measuring salivary cortisol in samples collected five times over one day. In addition, self-administered questionnaires were used to assess psychological variables. A time × group interaction effect was found (p = 0.003) in salivary cortisol secretion in response to stressful challenge. The healthy group presented normal activation, the SS and SLE groups showed no activation, and the SSc group presented a similar activation pattern to the HW group, except at the time of recovery. Total cortisol production (AUCg) was higher in the SSc group than in the HW group (p = 0.001). Differences were also observed in the cortisol AUCg collected over one day between healthy women and patients with SLE (p = 0.004) as well as with SSc (p = 0.001): women with SLE and SSc presented higher total hormone production than healthy women. Patients with autoimmune disease present a different HPA axis response, which may contribute to the harmful effects of stress in these diseases.
Sponsor: This study is part of a doctoral thesis and was supported by the I + D Project “PSI2010-15780” of the Spanish Ministry of Economy and Competitiveness.
URI: http://hdl.handle.net/10045/141324
ISSN: 1532-3005 (Print) | 1532-2998 (Online)
DOI: 10.1002/smi.3392
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2024 The Authors. Stress and Health published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Peer Review: si
Publisher version: https://doi.org/10.1002/smi.3392
Appears in Collections:INV - PSYBHE - Artículos de Revistas
INV - CV, BP Y S - Artículos de Revistas

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