Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas

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Title: Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas
Authors: Martínez Gil, Natalia | Kutsyr, Oksana | Fernández-Sánchez, Laura | Sánchez-Sáez, Xavier | Albertos Arranz, Henar | Sánchez-Castillo, Carla | Vidal Gil, Lorena | Cuenca, Nicolás | Lax, Pedro | Maneu, Victoria
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía
Keywords: TRPM7 | TRP | Ischemia | Reperfusion | Retina degeneration
Issue Date: 8-Nov-2023
Publisher: MDPI
Citation: Martínez-Gil N, Kutsyr O, Fernández-Sánchez L, Sánchez-Sáez X, Albertos-Arranz H, Sánchez-Castillo C, Vidal-Gil L, Cuenca N, Lax P, Maneu V. Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas. International Journal of Molecular Sciences. 2023; 24(22):16068.
Abstract: Ischemia is the main cause of cell death in retinal diseases such as vascular occlusions, diabetic retinopathy, glaucoma, or retinopathy of prematurity. Although excitotoxicity is considered the primary mechanism of cell death during an ischemic event, antagonists of glutamatergic receptors have been unsuccessful in clinical trials with patients suffering ischemia or stroke. Our main purpose was to analyze if the transient receptor potential channel 7 (TRPM7) could contribute to retinal dysfunction in retinal pathologies associated with ischemia. By using an experimental model of acute retinal ischemia, we analyzed the changes in retinal function by electroretinography and the changes in retinal morphology by optical coherence tomography (OCT) and OCT-angiography (OCTA). Immunohistochemistry was performed to assess the pattern of TRPM7 and its expression level in the retina. Our results show that ischemia elicited a decrease in retinal responsiveness to light stimuli along with reactive gliosis and a significant increase in the expression of TRPM7 in Müller cells. TRPM7 could emerge as a new drug target to be explored in retinal pathologies associated with ischemia.
Sponsor: We acknowledge financial support from the Ministerio de Ciencia e Innovación (FEDER-PID 2019-106230RB-I00), Ministerio de Universidades (FPU16/04114, FPU-18/02964). Generalitat Valenciana-FEDER (IDIFEDER/2017/064, PROMETEO/2021/024), Es Retina Asturias (2019/00286/001). MARSALAS21-35, financiado por la Unión Europea-Next Generation EU.
ISSN: 1422-0067
DOI: 10.3390/ijms242216068
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Peer Review: si
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Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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