Comparative Study of the Efficacy of EHO-85, a Hydrogel Containing Olive Tree (Olea europaea) Leaf Extract, in Skin Wound Healing
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Título: | Comparative Study of the Efficacy of EHO-85, a Hydrogel Containing Olive Tree (Olea europaea) Leaf Extract, in Skin Wound Healing |
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Autor/es: | Torrecillas-Baena, Bárbara | Camacho-Cardenosa, Marta | Carmona-Luque, María Dolores | Dorado, Gabriel | Berenguer Pérez, Miriam | Quesada-Gómez, José Manuel | Gálvez-Moreno, María Ángeles | Casado-Díaz, Antonio |
Grupo/s de investigación o GITE: | Grupo Winter Heridas: Wounds, Innovation, Therapeutics and Research (WINTER HERIDAS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia |
Palabras clave: | Hydrogel | Olea europaea leaf extract | Oleuropein | EHO-85 | Dexpanthenol | Centella asiatica | Hyaluronic acid | Wound healing | Skin |
Fecha de publicación: | 28-ago-2023 |
Editor: | MDPI |
Cita bibliográfica: | Torrecillas-Baena B, Camacho-Cardenosa M, Carmona-Luque MD, Dorado G, Berenguer-Pérez M, Quesada-Gómez JM, Gálvez-Moreno MÁ, Casado-Díaz A. Comparative Study of the Efficacy of EHO-85, a Hydrogel Containing Olive Tree (Olea europaea) Leaf Extract, in Skin Wound Healing. International Journal of Molecular Sciences. 2023; 24(17):13328. https://doi.org/10.3390/ijms241713328 |
Resumen: | Olive tree (Olea europaea) leaf extract (OELE) has important antioxidant and anti-inflammatory properties, supporting its use in human clinical practice. We recently designed an amorphous hydrogel called EHO-85 (EHO indicates olive leaf extract in Spanish) containing OELE for skin ulcer treatments. Yet, its effectiveness has not been previously compared with other products used in routine clinical practice. This is necessary to evaluate its potential translation to the human clinic. Thus, in this study, the effect of EHO-85 on healing was evaluated in comparison with treatments containing Indian/Asiatic pennywort (Centella asiatica), hyaluronic acid, or dexpanthenol in a rat model. The speed of wound closure and histological parameters after seven and 14 days were analyzed. All treatments accelerated wound closure, but there were differences between them. Dexpanthenol after seven days produced the highest epithelialization and the lowest inflammation and vascularization. EHO-85 also promoted epithelialization and reduced vascularization. After 14 days, wounds treated with EHO-85 showed less inflammation and higher levels of collagen in the extracellular matrix. This indicates a higher degree of maturity in the regenerated tissue. In conclusion, the effect of EHO-85 on healing was equal to or superior to that of other treatments routinely used in human clinical practice. Therefore, these results, together with previous data on the effects of this hydrogel on ulcer healing in humans, indicate that EHO-85 is a suitable, low-cost, and efficient therapeutic option for wound healing. |
Patrocinador/es: | This research was funded by Ministry of Economy and Competitiveness: INNCORPORA-TU-2011-1886; Department of Health, Regional Government of Andalusia: program for the Reinforcement of Research Activity in the Clinical Management Units of the Andalusian Health Service: A1-0047-2022; Noventure Grupo Ferrer Internacional (Barcelona, Spain): ESTUDIO GC-17-01; MD.C-L. is funded by Foundation for Biomedical Research of Cordoba through a junior postdoctoral contract from regional Ministry of Health (RH-0058-2021) and the European Regional Development Fund (FEDER). |
URI: | http://hdl.handle.net/10045/136903 |
ISSN: | 1422-0067 |
DOI: | 10.3390/ijms241713328 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/ijms241713328 |
Aparece en las colecciones: | INV - WINTER HERIDAS - Artículos de Revistas |
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