EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial
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Título: | EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial |
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Autor/es: | Verdú, José | Cristino-Espinar, Marisol de | Luna-Morales, Silvia | Dios-Guerra, Caridad | Casado-Díaz, Antonio | Quesada-Gómez, José Manuel | Dorado, Gabriel | Berenguer Pérez, Miriam | Vílchez, Susana | Esquena, Jordi | Rodríguez-Mañas, Leocadio | Lázaro-Martínez, José Luis |
Grupo/s de investigación o GITE: | Grupo Winter Heridas: Wounds, Innovation, Therapeutics and Research (WINTER HERIDAS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Enfermería Comunitaria, Medicina Preventiva y Salud Pública e Historia de la Ciencia |
Palabras clave: | Amorphous hydrogel | EHO-85 | Diabetic foot ulcer | Pressure ulcer | Randomized active-controlled trial | Venous leg ulcer |
Fecha de publicación: | 11-jul-2023 |
Editor: | MDPI |
Cita bibliográfica: | Verdú-Soriano J, de Cristino-Espinar M, Luna-Morales S, Dios-Guerra C, Casado-Díaz A, Quesada-Gómez JM, Dorado G, Berenguer-Pérez M, Vílchez S, Esquena J, et al. EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial. Pharmaceutics. 2023; 15(7):1925. https://doi.org/10.3390/pharmaceutics15071925 |
Resumen: | Many advanced wound healing dressings exist, but there is little high-quality evidence to support them. To determine the performance of a novel amorphous hydrogel (EHO-85) in relation to its application, we compared its rheological properties with those of other standard hydrogels (SH), and we assessed the induction of acceleration of the early stages of wound healing as a secondary objective of a prospective, multicenter, randomized, observer-blinded, controlled trial. The patients were recruited if they had pressure, venous, or diabetic foot ulcers and were treated with EHO-85 (n = 103) or VariHesive® (SH) (n = 92), and their response was assessed by intention-to-treat as wound area reduction (WAR (%)) and healing rate (HR mm2/day) in the second and fourth weeks of treatment. Results: EHO-85 had the highest shear thinning and G′/G″ ratio, the lowest viscous modulus, G″, and relatively low cohesive energy; EHO-85 had a significantly superior effect over SH in WAR and HR, accelerating wound healing in the second and fourth weeks of application (p: 0.002). This superiority is likely based on its optimal moisturizing capacity and excellent pH-lowering and antioxidant properties. In addition, the distinct shear thinning of EHO-85 facilitates spreading by gentle hand pressure, making it easier to apply to wounds. These rheological properties contribute to its improved performance. |
Patrocinador/es: | This research was developed by QUESPER R&D, and partially funded by INNCORPORA-TU-2011-1886 subprogram (Ministry of Economy and Competitiveness, Spain) and the programme for the Reinforcement of Research Activity in the Clinical Management Units of the Andalusian Health Service (Department of Health, Regional Government of Andalusia, Spain). The characterization of rheological properties was financed by Noventure, Ferrer company group. |
URI: | http://hdl.handle.net/10045/136196 |
ISSN: | 1999-4923 |
DOI: | 10.3390/pharmaceutics15071925 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/pharmaceutics15071925 |
Aparece en las colecciones: | INV - WINTER HERIDAS - Artículos de Revistas |
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