1,3-Bis(3-carboxypropyl)-1H-imidazole
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http://hdl.handle.net/10045/129116
| Title: | 1,3-Bis(3-carboxypropyl)-1H-imidazole |
|---|---|
| Authors: | Martos, Mario | Albert-Soriano, María | Pastor, Isidro M. |
| Research Group/s: | Alternative Methodologies In Chemistry (AMIC) |
| Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
| Keywords: | Imidazole | γ-aminobutyric acid | Zwitterion | Multicomponent reaction |
| Issue Date: | 4-Nov-2022 |
| Publisher: | MDPI |
| Citation: | Martos M, Albert-Soriano M, Pastor IM. 1,3-Bis(3-carboxypropyl)-1H-imidazole. Molbank. 2022; 2022(4):M1480. https://doi.org/10.3390/M1480 |
| Abstract: | The use of γ-aminobutyric acid (GABA) as a starting material in a multicomponent reaction has resulted in the preparation of the zwitterionic 1,3-bis(3-carboxypropyl)imidazole (bcpim). The synthesis of this imidazole derivative in a one-pot procedure with stoichiometric amounts of the corresponding reagents (formaldehyde, glyoxal, and GABA in a 1:1:2 ratio) has resulted in a straightforward and effective methodology, meaning a significant improvement from a sustainable point of view. |
| Sponsor: | This research was funded by Ministerio de Ciencia, Innovación y Universidades (grant number PGC2018-096616-B-I00), Ministerio de Ciencia e Innovación (PID2021-127332NB-I00), Generalitat Valenciana (grant number AICO/2021/013), and the University of Alicante (grant number VIGROB-316). |
| URI: | http://hdl.handle.net/10045/129116 |
| ISSN: | 1422-8599 |
| DOI: | 10.3390/M1480 |
| Language: | eng |
| Type: | info:eu-repo/semantics/article |
| Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Peer Review: | si |
| Publisher version: | https://doi.org/10.3390/M1480 |
| Appears in Collections: | INV - AMIC - Artículos de Revistas |
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| File | Description | Size | Format | |
|---|---|---|---|---|
 Martos_etal_2022_Molbank.pdf | 620,11 kB | Adobe PDF | Open Preview | |
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