The pancreatic β-cell in ageing: Implications in age-related diabetes
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Título: | The pancreatic β-cell in ageing: Implications in age-related diabetes |
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Autor/es: | Tudurí, Eva | Soriano, Sergi | Almagro, Lucía | Montanya, Eduard | Alonso Magdalena, Paloma | Nadal, Ángel | Quesada, Iván |
Grupo/s de investigación o GITE: | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) | Fisiología Neuroendocrina (FINE) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología |
Palabras clave: | Ageing | Insulin secretion | Pancreatic beta-cell function | Pancreatic beta-cell mass | Senescence | Diabetes |
Fecha de publicación: | 17-jun-2022 |
Editor: | Elsevier |
Cita bibliográfica: | Ageing Research Reviews. 2022, 80: 101674. https://doi.org/10.1016/j.arr.2022.101674 |
Resumen: | The prevalence of type 2 diabetes (T2D) and impaired glucose tolerance (IGT) increases with ageing. T2D generally results from progressive impairment of the pancreatic islets to adapt β-cell mass and function in the setting of insulin resistance and increased insulin demand. Several studies have shown an age-related decline in peripheral insulin sensitivity. However, a precise understanding of the pancreatic β-cell response in ageing is still lacking. In this review, we summarize the age-related alterations, adaptations and/or failures of β-cells at the molecular, morphological and functional levels in mouse and human. Age-associated alterations include processes such as β-cell proliferation, apoptosis and cell identity that can influence β-cell mass. Age-related changes also affect β-cell function at distinct steps including electrical activity, Ca2+ signaling and insulin secretion, among others. We will consider the potential impact of these alterations and those mediated by senescence pathways on β-cells and their implications in age-related T2D. Finally, given the great diversity of results in the field of β-cell ageing, we will discuss the sources of this heterogeneity. A better understanding of β-cell biology during ageing, particularly at older ages, will improve our insight into the contribution of β-cells to age-associated T2D and may boost new therapeutic strategies. |
Patrocinador/es: | This research was supported by grants from the Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación, Fondo Europeo de Desarrollo Regional (FEDER), Instituto de Salud Carlos III and Generalitat Valenciana: PID2020-117294RB-I00 and PROMETEO/2020/006 to AN, BFU2016-77125-R to IQ, PID2020-113112RB-I00 to PAM and PI19/00246 to EM. CIBERDEM is an initiative of the Instituto de Salud Carlos III. |
URI: | http://hdl.handle.net/10045/126200 |
ISSN: | 1568-1637 (Print) | 1872-9649 (Online) |
DOI: | 10.1016/j.arr.2022.101674 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1016/j.arr.2022.101674 |
Aparece en las colecciones: | INV - FINE - Artículos de Revistas INV - NEUROVIS - Artículos de Revistas |
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Tuduri_etal_2022_AgeingResRev.pdf | 1,65 MB | Adobe PDF | Abrir Vista previa | |
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