N,N-Diethyl-3-methylbenzamide
Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10045/124699
Título: | N,N-Diethyl-3-methylbenzamide |
---|---|
Autor/es: | Albert-Soriano, María | Pastor, Isidro M. |
Grupo/s de investigación o GITE: | Alternative Methodologies In Chemistry (AMIC) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Palabras clave: | Amide | Copper | Heterogeneous catalysis | Metal-organic framework | Oxidative coupling |
Área/s de conocimiento: | Química Orgánica |
Fecha de publicación: | 25-jun-2022 |
Editor: | MDPI |
Cita bibliográfica: | Albert-Soriano M, Pastor IM. N,N-Diethyl-3-methylbenzamide. Molbank. 2022; 2022(3):M1395. https://doi.org/10.3390/M1395 |
Resumen: | The development of new techniques for the preparation of organic compounds is important, with catalytic processes being key to this innovation. The development of copper-based metal-organic frameworks to promote oxidative couplings has allowed the synthesis of amides in a very effective manner. This methodology has been successfully applied to the unique preparation of the bioactive compound N,N-diethyl-3-methylbenzamide, with excellent performance (>99% conversion and 95% yield of pure isolated product) on a preparative scale. The described procedure can be classified as an excellent synthesis (EcoScale) considering environmental and economic factors based on different “green metrics” (atom economy, reaction mass efficiency, materials recovery factor, stoichiometric factor, E-factor). |
Patrocinador/es: | This research was funded by Ministerio de Ciencia, Innovación y Universidades (grant number PGC2018-096616-B-I00), Ministerio de Educación, Cultura y Deporte (grant number FPU15/06040), Generalitat Valenciana (grant number AICO/2021/013) and the University of Alicante (grant number VIGROB-316). |
URI: | http://hdl.handle.net/10045/124699 |
ISSN: | 1422-8599 |
DOI: | 10.3390/M1395 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/M1395 |
Aparece en las colecciones: | INV - AMIC - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Albert-Soriano_Pastor_2022_Molbank.pdf | 651,25 kB | Adobe PDF | Abrir Vista previa | |
Este ítem está licenciado bajo Licencia Creative Commons