Nature and nurture. Genetic and environmental factors on the relationship between back pain and sleep quality
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http://hdl.handle.net/10045/123561
Title: | Nature and nurture. Genetic and environmental factors on the relationship between back pain and sleep quality |
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Authors: | Madrid-Valero, Juan J. | Andreucci, Alessandro | Carrillo, Eduvigis | Ferreira, Paulo H. | Martínez-Selva, Jose M. | Ordoñana, Juan R. |
Research Group/s: | Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE) |
Center, Department or Service: | Universidad de Alicante. Departamento de Psicología de la Salud |
Keywords: | Low Back Pain | Neck Pain | Sleep Quality | Twins |
Knowledge Area: | Psicología Básica |
Issue Date: | 10-May-2022 |
Publisher: | Wiley |
Citation: | European Journal of Pain. 2022, 26(7): 1460-1468. https://doi.org/10.1002/ejp.1973 |
Abstract: | Background: Chronic low back pain (LBP), neck pain (NP), and sleep quality (SQ) are genetically influenced. All three conditions frequently co-occur and shared genetic etiology on a pairwise base has been reported. However, to our knowledge no study has yet investigated if these three conditions are influenced by the same genetic and environmental factors and the extent and pattern of genetic overlap between them, hence the current research. Methods: The sample included 2134 participants. Lifetime prevalence of NP and LBP were assessed through a dichotomous self-reported question derived from the Spanish National Health Survey. SQ was measured using the Pittsburgh Sleep Quality Index Questionnaire. A common pathway model with sleep quality and back pain as latent factors was fitted. Results: Our results highlight that a latent back pain factor, including both NP and LBP, is explained by both genetic (41%) and environmental (59%) factors. There are also significant unique environmental factors for NP (33%) and LBP (37%) respectively. Yet, specific genetic factors were scant (9%) for NP and negligible for LBP (0%). Genetic and environmental factors affecting SQ only contribute with 3% and 5% of the variance, respectively, to the common latent back pain variable. Conclusions: NP and LBP share most of their genetic variance, while environmental effects show greater specificity for each of the back pain locations. Associations with SQ were of a limited magnitude. |
Sponsor: | Ministerio de Ciencia, Innovación y Universidades - Spain (RTI2018-095185-B-I00) co-funded by European Regional Development Fund (FEDER). |
URI: | http://hdl.handle.net/10045/123561 |
ISSN: | 1532-2149 |
DOI: | 10.1002/ejp.1973 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © 2022 The Authors. European Journal of Pain published by John Wiley & Sons Ltd on behalf of European Pain Federation - EFIC®. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
Peer Review: | si |
Publisher version: | https://doi.org/10.1002/ejp.1973 |
Appears in Collections: | INV - PSYBHE - Artículos de Revistas |
Files in This Item:
File | Description | Size | Format | |
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Madrid-Valero_etal_2022_EurJPain.pdf | 212,32 kB | Adobe PDF | Open Preview | |
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