Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review
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Título: | Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review |
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Autor/es: | Boned-Murillo, Ana | Albertos Arranz, Henar | Diaz-Barreda, María Dolores | Orduna, Elvira | Sánchez Cano, Ana | Ferreras, Antonio | Cuenca, Nicolás | Pinilla Lozano, Isabel |
Grupo/s de investigación o GITE: | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología |
Palabras clave: | Diabetes mellitus | Diabetic retinopathy | Foveal avascular zone | FAZ | Optical coherence tomography angiography | OCTA | Diabetic macular oedema |
Área/s de conocimiento: | Biología Celular |
Fecha de publicación: | 31-dic-2021 |
Editor: | MDPI |
Cita bibliográfica: | Boned-Murillo A, Albertos-Arranz H, Diaz-Barreda MD, Orduna-Hospital E, Sánchez-Cano A, Ferreras A, Cuenca N, Pinilla I. Optical Coherence Tomography Angiography in Diabetic Patients: A Systematic Review. Biomedicines. 2022; 10(1):88. https://doi.org/10.3390/biomedicines10010088 |
Resumen: | Background: Diabetic retinopathy (DR) is the leading cause of legal blindness in the working population in developed countries. Optical coherence tomography (OCT) angiography (OCTA) has risen as an essential tool in the diagnosis and control of diabetic patients, with and without DR, allowing visualisation of the retinal and choroidal microvasculature, their qualitative and quantitative changes, the progression of vascular disease, quantification of ischaemic areas, and the detection of preclinical changes. The aim of this article is to analyse the current applications of OCTA and provide an updated overview of them in the evaluation of DR. Methods: A systematic literature search was performed in PubMed and Embase, including the keywords “OCTA” OR “OCT angiography” OR “optical coherence tomography angiography” AND “diabetes” OR “diabetes mellitus” OR “diabetic retinopathy” OR “diabetic maculopathy” OR “diabetic macular oedema” OR “diabetic macular ischaemia”. Of the 1456 studies initially identified, 107 studies were screened after duplication, and those articles that did not meet the selection criteria were removed. Finally, after looking for missing data, we included 135 studies in this review. Results: We present the common and distinctive findings in the analysed papers after the literature search including the diagnostic use of OCTA in diabetes mellitus (DM) patients. We describe previous findings in retinal vascularization, including microaneurysms, foveal avascular zone (FAZ) changes in both size and morphology, changes in vascular perfusion, the appearance of retinal microvascular abnormalities or new vessels, and diabetic macular oedema (DME) and the use of deep learning technology applied to this disease. Conclusion: OCTA findings enable the diagnosis and follow-up of DM patients, including those with no detectable lesions with other devices. The evaluation of retinal and choroidal plexuses using OCTA is a fundamental tool for the diagnosis and prognosis of DR. |
Patrocinador/es: | Spanish Ministry of Universities (FPU18/02964) and the Health Research Fund Instituto de Salud Carlos III (Fondo de Investigación Sanitaria, Spanish Ministry of Health) PI20/00740. |
URI: | http://hdl.handle.net/10045/121535 |
ISSN: | 2227-9059 |
DOI: | 10.3390/biomedicines10010088 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/biomedicines10010088 |
Aparece en las colecciones: | INV - NEUROVIS - Artículos de Revistas |
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