Catalase as a Molecular Target for Male Infertility Diagnosis and Monitoring: An Overview
Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10045/101498
Título: | Catalase as a Molecular Target for Male Infertility Diagnosis and Monitoring: An Overview |
---|---|
Autor/es: | Rubio-Riquelme, Nuria | Huerta-Retamal, Natalia | Gómez-Torres, María José | Martínez-Espinosa, Rosa María |
Grupo/s de investigación o GITE: | Grupo de Inmunología, Biología Celular y del Desarrollo | Bioquímica Aplicada/Applied Biochemistry (AppBiochem) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Biotecnología | Universidad de Alicante. Departamento de Agroquímica y Bioquímica |
Palabras clave: | Catalase | Reactive oxygen species (ROS) | Oxidative stress | Male fertility |
Área/s de conocimiento: | Biología Celular | Bioquímica y Biología Molecular |
Fecha de publicación: | 16-ene-2020 |
Editor: | MDPI |
Cita bibliográfica: | Rubio-Riquelme N, Huerta-Retamal N, Gómez-Torres MJ, Martínez-Espinosa RM. Catalase as a Molecular Target for Male Infertility Diagnosis and Monitoring: An Overview. Antioxidants. 2020; 9(1):78. doi:10.3390/antiox9010078 |
Resumen: | Catalase (CAT) stands out as one of the most efficient natural enzymes when catalysing the split of H2O2 into H2O and O2; H2O2 is one of the reactive oxygen species (ROS) involved in oxidative stress, a process closely related to aging and several health disorders or diseases like male infertility. Some studies have correlated H2O2 with male infertility and catalase with fertility restoration. However, the number of studies conducted with human beings remains scarce. Considering the use of CAT as a molecular target for biochemical analysis, this review summarises the current knowledge on how CAT influences human beings’ male fertility. Thus, three different databases were consulted—Scopus, PubMed and WOS—using single keywords and combinations thereof. A total of 40,823 articles were identified. Adopting inclusion and exclusion criteria, a final database of 197 articles served to conduct this work. It follows from this analysis that CAT could play an important role in male fertility and could become a good target for male infertility diagnosis and monitoring. However, that potential role of CAT as a tool in diagnosis must be confirmed by clinical trials. Finally, guidelines are suggested to reinforce the use of CAT in daily clinical tests for male fertility diagnosis and monitoring. |
Patrocinador/es: | This research was funded by the Human Fertility Chair, the Department of Biotechnology (VIGROB-186) and the Applied Biochemistry research group of the University of Alicante (VIGROB-309). |
URI: | http://hdl.handle.net/10045/101498 |
ISSN: | 2076-3921 |
DOI: | 10.3390/antiox9010078 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/antiox9010078 |
Aparece en las colecciones: | INV - AppBiochem - Artículos de Revistas INV - Grupo de Inmunología - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2020_Rubio-Riquelme_etal_Antioxidants.pdf | 965,03 kB | Adobe PDF | Abrir Vista previa | |
Este ítem está licenciado bajo Licencia Creative Commons