Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System
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Título: | Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System |
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Autor/es: | Tacias-Pascacio, Veymar G. | Ortiz, Claudia | Rueda, Nazzoly | Berenguer-Murcia, Ángel | Acosta, Niuris | Aranaz, Inmaculada | Civera, Concepción | Fernandez Lafuente, Roberto | Alcántara, Andrés R. |
Grupo/s de investigación o GITE: | Materiales Carbonosos y Medio Ambiente |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Inorgánica | Universidad de Alicante. Instituto Universitario de Materiales |
Palabras clave: | Dextran | Dextran-aldehyde | Enzyme immobilization | Enzyme modification |
Área/s de conocimiento: | Química Inorgánica |
Fecha de publicación: | 21-jul-2019 |
Editor: | MDPI |
Cita bibliográfica: | Tacias-Pascacio VG, Ortiz C, Rueda N, Berenguer-Murcia Á, Acosta N, Aranaz I, Civera C, Fernandez-Lafuente R, Alcántara AR. Dextran Aldehyde in Biocatalysis: More Than a Mere Immobilization System. Catalysts. 2019; 9(7):622. doi:10.3390/catal9070622 |
Resumen: | Dextran aldehyde (dexOx), resulting from the periodate oxidative cleavage of 1,2-diol moiety inside dextran, is a polymer that is very useful in many areas, including as a macromolecular carrier for drug delivery and other biomedical applications. In particular, it has been widely used for chemical engineering of enzymes, with the aim of designing better biocatalysts that possess improved catalytic properties, making them more stable and/or active for different catalytic reactions. This polymer possesses a very flexible hydrophilic structure, which becomes inert after chemical reduction; therefore, dexOx comes to be highly versatile in a biocatalyst design. This paper presents an overview of the multiple applications of dexOx in applied biocatalysis, e.g., to modulate the adsorption of biomolecules on carrier surfaces in affinity chromatography and biosensors design, to serve as a spacer arm between a ligand and the support in biomacromolecule immobilization procedures or to generate artificial microenvironments around the enzyme molecules or to stabilize multimeric enzymes by intersubunit crosslinking, among many other applications. |
Patrocinador/es: | This research was funded by the Ministry of Science, Innovation and Universities from Spanish Government (project numbers MAT2015-65184-C2-1_R and CTQ2017-86170-R) and Colciencias (Colombia) (project number FP 44842-076-2016). |
URI: | http://hdl.handle.net/10045/95398 |
ISSN: | 2073-4344 |
DOI: | 10.3390/catal9070622 |
Idioma: | spa |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/catal9070622 |
Aparece en las colecciones: | INV - MCMA - Artículos de Revistas |
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2019_Tacias-Pascacio_etal_Catalysts.pdf | 11,74 MB | Adobe PDF | Abrir Vista previa | |
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