Enantioselective Michael Addition of Aldehydes to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide
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Campo DC | Valor | Idioma |
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dc.contributor | Catálisis Estereoselectiva en Síntesis Orgánica (CESO) | es_ES |
dc.contributor.author | Torregrosa-Chinillach, Alejandro | - |
dc.contributor.author | Moragues, Adrien | - |
dc.contributor.author | Pérez-Furundarena, Haritz | - |
dc.contributor.author | Chinchilla, Rafael | - |
dc.contributor.author | Gómez Bengoa, Enrique | - |
dc.contributor.author | Guillena, Gabriela | - |
dc.contributor.other | Universidad de Alicante. Departamento de Química Orgánica | es_ES |
dc.contributor.other | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica | es_ES |
dc.date.accessioned | 2018-12-13T08:58:35Z | - |
dc.date.available | 2018-12-13T08:58:35Z | - |
dc.date.issued | 2018-12-12 | - |
dc.identifier.citation | Torregrosa-Chinillach A, Moragues A, Pérez-Furundarena H, Chinchilla R, Gómez-Bengoa E, Guillena G. Enantioselective Michael Addition of Aldehydes to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide. Molecules. 2018; 23(12):3299. doi:10.3390/molecules23123299 | es_ES |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/10045/84768 | - |
dc.description.abstract | A primary amine-salicylamide derived from chiral trans-cyclohexane-1,2-diamine was used as an organocatalyst for the enantioselective conjugate addition of aldehydes, mainly α,α-disubstituted to N-substituted maleimides. The reaction was performed in toluene as a solvent at room temperature. The corresponding enantioenriched adducts were obtained with high yields and enantioselectivities up to 94%. Theoretical calculations were used to justify the stereoinduction. | es_ES |
dc.description.sponsorship | We thank the financial support from the Spanish Ministerio de Economía, Industria y Competitividad (CTQ2015-66624-P and CTQ201788171-P) and the University of Alicante (VIGROB-173). A.M. thanks SIGMA Clermont Chemistry Engineering Graduate School for an ERASMUS+ fellowship. We also thank the Basque Government (GIC15/03, IT1033-16) for financial support, and IZO/SGI SGIker of UPV/EHU for human and technical support. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.subject | Organocatalysis | es_ES |
dc.subject | Asymmetric synthesis | es_ES |
dc.subject | Michael addition | es_ES |
dc.subject | Maleimides | es_ES |
dc.subject | Aldehydes | es_ES |
dc.subject.other | Química Orgánica | es_ES |
dc.title | Enantioselective Michael Addition of Aldehydes to Maleimides Organocatalyzed by a Chiral Primary Amine-Salicylamide | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.peerreviewed | si | es_ES |
dc.identifier.doi | 10.3390/molecules23123299 | - |
dc.relation.publisherversion | https://doi.org/10.3390/molecules23123299 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CTQ2015-66624-P | - |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-88171-P | - |
Aparece en las colecciones: | INV - CESO - Artículos de Revistas |
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2018_Torregrosa-Chinillach_etal_Molecules.pdf | 784,74 kB | Adobe PDF | Abrir Vista previa | |
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