Levels of dioxin-like PCBs in low-volume serum samples of male patients attending fertility clinics
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Título: | Levels of dioxin-like PCBs in low-volume serum samples of male patients attending fertility clinics |
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Autor/es: | Moltó Berenguer, Julia | Paul, Raiza | Ortuño García, Nuria | Medrano, María Llanos | Aizpurua, Jon | Gómez-Torres, María José |
Grupo/s de investigación o GITE: | Residuos, Energía, Medio Ambiente y Nanotecnología (REMAN) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Ingeniería Química | Universidad de Alicante. Departamento de Biotecnología |
Palabras clave: | Human serum | Male infertility | DL-PCBs | HRGC-HRMS | Pollutants | Analytical method |
Área/s de conocimiento: | Ingeniería Química | Biología Celular |
Fecha de publicación: | 21-oct-2015 |
Editor: | Springer Berlin Heidelberg |
Cita bibliográfica: | Environmental Science and Pollution Research. 2015. doi:10.1007/s11356-015-5571-7 |
Resumen: | An accurate and easy method for the extraction, cleanup, and HRGC-HRMS analysis of dioxin-like PCBs (DL-PCBs) in low-volume serum samples (1 mL) was developed. Serum samples were extracted several times using n-hexane and purified by acid washing. Recovery rates of labeled congeners ranged from 70 to 110 % and the limits of detection were below 1 pg/g on lipid basis. Although human studies are limited and contradictory, several studies have shown that DL-PCBs can have adverse effects on the male reproductive system. In this way, the present method was applied to 21 serum samples of male patients attending fertility clinics. The total levels obtained for the patients ranged from 6.90 to 84.1 pg WHO-TEQ/g lipid, with a mean value of 20.3 pg WHO-TEQ/g lipid. The predominant PCBs (the sum of PCB 118, 156, and 105) contributed 67 % to the mean concentration of total DL-PCBs in the samples analyzed. |
Patrocinador/es: | Support for this work was provided by the CTQ2013-41006-R project from the Ministry of Economy and Competitiveness (Spain), the PROMETEOII/2014/007 project from the Valencian Community Government (Spain), and the Chair of Human Fertility of the University of Alicante (Spain). |
URI: | http://hdl.handle.net/10045/50568 |
ISSN: | 0944-1344 (Print) | 1614-7499 (Online) |
DOI: | 10.1007/s11356-015-5571-7 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © Springer-Verlag Berlin Heidelberg 2015. The final publication is available at Springer via http://dx.doi.org/10.1007/s11356-015-5571-7 |
Revisión científica: | si |
Versión del editor: | http://dx.doi.org/10.1007/s11356-015-5571-7 |
Aparece en las colecciones: | INV - REMAN - Artículos de Revistas INV - I4CE - Artículos de Revistas |
Archivos en este ítem:
Archivo | Descripción | Tamaño | Formato | |
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2015_Molto_etal_EnvironSciPollutRes_final.pdf | Versión final (acceso restringido) | 1,17 MB | Adobe PDF | Abrir Solicitar una copia |
2015_Molto_etal_EnvironSciPollutRes_revised.pdf | Versión revisada (acceso abierto) | 894,54 kB | Adobe PDF | Abrir Vista previa |
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