Recent Advances on the Catalytic Asymmetric Allylic α‑Alkylation of Carbonyl Derivatives Using Free Allylic Alcohols
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Título: | Recent Advances on the Catalytic Asymmetric Allylic α‑Alkylation of Carbonyl Derivatives Using Free Allylic Alcohols |
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Autor/es: | Alonso, Diego A. | Maciá Ruiz, Beatriz | Pastor, Isidro M. | Baeza, Alejandro |
Grupo/s de investigación o GITE: | Catálisis Estereoselectiva en Síntesis Orgánica (CESO) | Alternative Methodologies In Chemistry (AMIC) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
Palabras clave: | Asymmetric catalysis | Allylic alcohols | Carbonyl compounds | Allylic alkylation | Green chemistry | Organocatalysis | Metal catalysis | Natural products |
Fecha de publicación: | 10-feb-2024 |
Editor: | American Chemical Society |
Cita bibliográfica: | ACS Organic & Inorganic Au. 2024. https://doi.org/10.1021/acsorginorgau.3c00065 |
Resumen: | During the last years, the development of more sustainable and straightforward methodologies to minimize the generation of waste organic substances has acquired high importance within synthetic organic chemistry. Therefore, it is not surprising that many efforts are devoted to ameliorating already well-known successful methodologies, that is, the case of the asymmetric allylic allylation reaction of carbonyl compounds. The use of free alcohols as alkylating agents in this transformation represents a step forward in this sense since it minimizes waste production and the substrate manipulation. In this review, we aim to gather the most recent methodologies describing this strategy by paying special attention to the reaction mechanisms, as well as their synthetic applications. |
Patrocinador/es: | We would like to thank the Spanish Ministerio de Ciencia e Innovación (PID2021-127332NB-I00); Conselleria d’Innovació, Universitats, Ciència i Societat Digital de la Generalitat Valenciana (AICO/2021/013); and the University of Alicante (VIGROB-316 and VIGROB-173) for the financial support. |
URI: | http://hdl.handle.net/10045/140750 |
ISSN: | 2694-247X |
DOI: | 10.1021/acsorginorgau.3c00065 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2024 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1021/acsorginorgau.3c00065 |
Aparece en las colecciones: | INV - CESO - Artículos de Revistas INV - AMIC - Artículos de Revistas |
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Alonso_etal_2024_ACSOrgInorgAu.pdf | 4,57 MB | Adobe PDF | Abrir Vista previa | |
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