Highly emissive hybrid mesoporous organometallo-silica nanoparticles for bioimaging
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Título: | Highly emissive hybrid mesoporous organometallo-silica nanoparticles for bioimaging |
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Autor/es: | Ezquerro, Cintia | López, Icíar | Serrano, Elena | Alfaro-Arnedo, Elvira | Lalinde, Elena | Larráyoz, Ignacio | García Pichel, José | Garcia-Martinez, Javier | Berenguer, Jesús R. |
Grupo/s de investigación o GITE: | Laboratorio de Nanotecnología Molecular (NANOMOL) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Inorgánica |
Palabras clave: | Mesoporous Organometallo-Silica Nanoparticles | Highly luminescent | Synthesis | Superficial functionalization | Bioimaging |
Área/s de conocimiento: | Química Inorgánica |
Fecha de publicación: | 5-mar-2022 |
Editor: | American Chemical Society |
Cita bibliográfica: | Materials Advances. 2022, 3: 3582-3592. https://doi.org/10.1039/D1MA01243F |
Resumen: | Production of mesoporous silica nanoparticles (MSNs) with uniform textural characteristics and imaging properties on a large scale is still a challenge. Thus, the design of simple and scalable methods to obtain reproducible functionalized MSNs has become even more relevant. Herein, we describe an in situ strategy for the synthesis and surface functionalization of highly luminescent mesoporous organometallo-silica nanoparticles. Using the [Ir(dfppy)2(dasipy)]PF6 chromophore and TEOS as sol–gel precursors and different capping agents, such as DMDES or APTES, three different emissive MSNs were prepared (NPOH_IS, NPMe_IS and NPNH2_IS), each containing hydroxyl, methyl and amine groups on their surfaces, respectively. All three were tested on human tumor A549 (lung carcinoma) and HeLa (cervix carcinoma) cell lines, showing intense and stable yellow phosphorescence, biocompatibility and efficient internalization. Moreover, NPMe_IS nanoparticles showed excellent colloidal stability, both in water and biological media, and a BET area of 1120 m2 g−1, making them not only luminescent biomarkers, but potentially also controlled delivery vectors. |
Patrocinador/es: | This work was supported by the Spanish MCIN/AIE/10.13039/501100011033 and by “ERDF A way of making Europe”, by the “European Union” (projects CTQ2015-74494-JIN, RTI2018-099504-B-C21 and PID2019-109742GB-I00) and the Agencia de Desarrollo Económico de La Rioja (Gobierno de la Rioja. Project 2017-I-IDD-00031). E.S. also thanks the University of Alicante through the “Programa de Retención de Talento” (ref. UATALENTO16-03). E.A.-A. is grateful to the Spanish Association Against Cancer (AECC) for her Ph.D. fellowship. |
URI: | http://hdl.handle.net/10045/122129 |
ISSN: | 2633-5409 |
DOI: | 10.1039/D1MA01243F |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1039/D1MA01243F |
Aparece en las colecciones: | INV - NANOMOL - Artículos de Revistas |
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