Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa
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Título: | Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa |
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Autor/es: | Fuentes-Broto, Lorena | Perdices, Lorena | Segura, Francisco | Orduna, Elvira | Insa-Sánchez, Gema | Sánchez Cano, Ana | Cuenca, Nicolás | Pinilla Lozano, Isabel |
Grupo/s de investigación o GITE: | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología |
Palabras clave: | Retinitis pigmentosa | Antioxidant | Melatonin | Oxidative stress | Neurodegeneration | Circadian rhythms | Vision | Retina |
Área/s de conocimiento: | Biología Celular |
Fecha de publicación: | 22-nov-2021 |
Editor: | MDPI |
Cita bibliográfica: | Fuentes-Broto L, Perdices L, Segura F, Orduna-Hospital E, Insa-Sánchez G, Sánchez-Cano AI, Cuenca N, Pinilla I. Effects of Daily Melatonin Supplementation on Visual Loss, Circadian Rhythms, and Hepatic Oxidative Damage in a Rodent Model of Retinitis Pigmentosa. Antioxidants. 2021; 10(11):1853. https://doi.org/10.3390/antiox10111853 |
Resumen: | Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by a progressive loss of visual function that primarily affect photoreceptors, resulting in the complete disorganization and remodeling of the retina. Progression of the disease is enhanced by increased oxidative stress in the retina, aqueous humor, plasma, and liver of RP animal models and patients. Melatonin has beneficial effects against age-related macular degeneration, glaucoma, and diabetic retinopathy, in which oxidative stress plays a key role. In the present study, we used the P23HxLE rat as an animal model of RP. Melatonin treatment (10 mg/kg b.w. daily in drinking water for 6 months) improved the parameters of visual function and decreased the rate of desynchronization of the circadian rhythm, both in P23HxLE and wild-type rats. Melatonin reduced oxidative stress and increased antioxidant defenses in P23HxLE animals. In wild-type animals, melatonin did not modify any of the oxidative stress markers analyzed and reduced the levels of total antioxidant defenses. Treatment with melatonin improved visual function, circadian synchronization, and hepatic oxidative stress in P23HxLE rats, an RP model, and had beneficial effects against age-related visual damage in wild-type rats. |
Patrocinador/es: | This research was funded by the Instituto de Salud Carlos III Ocular Pathology National Net RETICS-Oftared (RD16/0008) and project PI13/01124; the Government of Aragon (Group B08_17R and a predoctoral grant to L. Perdices, C060/2014); and Fondo Europeo de Desarrollo Regional (FEDER) funds: “Una manera de hacer Europa”. |
URI: | http://hdl.handle.net/10045/120022 |
ISSN: | 2076-3921 |
DOI: | 10.3390/antiox10111853 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/antiox10111853 |
Aparece en las colecciones: | INV - NEUROVIS - Artículos de Revistas |
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