Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units
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| Título: | Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units |
|---|---|
| Autor/es: | Poyraz, Samet | Belveren, Samet | Aydınoğlu, Sabriye | Ülger, Mahmut | Cózar Ruano, Abel de | Retamosa, Maria de Gracia | Sansano, Jose M. | Dondas, H. Ali |
| Grupo/s de investigación o GITE: | Síntesis Asimétrica (SINTAS) |
| Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
| Palabras clave: | Antituberculosis | Bidentate ligands | DFT | Nickel | Palladium |
| Área/s de conocimiento: | Química Orgánica |
| Fecha de publicación: | 2-dic-2021 |
| Editor: | Beilstein-Institut |
| Cita bibliográfica: | Beilstein Journal of Organic Chemistry. 2021, 17: 2812-2821. https://doi.org/10.3762/bjoc.17.192 |
| Resumen: | A series of novel palladium(II) and nickel(II) complexes of multifunctionalized aroylaminocarbo-N-thioylpyrrolinates were synthesized and characterized by analytical and spectroscopic techniques. The biological properties of the freshly prepared compounds were screened against S. aureus, B. subtilis, A. hydrophila, E. coli, and A. baumannii bacteria and antituberculosis activity against M. tuberculosis H37Rv strains. Also, the antifungal activity was studied against C. albicans, C. tropicalis, and C. glabrata standard strains. A deep conformational survey was monitored using DFT calculations with the aim to explain the importance of the final conformation in the biological experimental results. |
| Patrocinador/es: | This work is a part of Samet POYRAZ's ongoing Ph.D. thesis granted by Mersin University (Project no. 2019-1-TP3-3463). We gratefully acknowledge financial support from Çukurova University and Mersin University (Project no. 2020-1-AP4-3982). We gratefully acknowledge financial support from the Spanish Ministerio de Ciencia, Innovación y Universidades (projects CTQ2016-81893REDT, and RED2018-102387-T) the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P, CTQ2016-80375-P, CTQ2017-82935-P and PID2019-107268GB-I00), the Generalitat Valenciana (IDIFEDER/2021/013, CIDEGENT/2020/058). |
| URI: | http://hdl.handle.net/10045/119931 |
| ISSN: | 1860-5397 |
| DOI: | 10.3762/bjoc.17.192 |
| Idioma: | eng |
| Tipo: | info:eu-repo/semantics/article |
| Derechos: | © 2021 Poyraz et al.; licensee Beilstein-Institut. This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material. |
| Revisión científica: | si |
| Versión del editor: | https://doi.org/10.3762/bjoc.17.192 |
| Aparece en las colecciones: | INV - SINTAS - Artículos de Revistas |
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| Archivo | Descripción | Tamaño | Formato | |
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 Poyraz_etal_2021_BeilsteinJOrgChem.pdf | 2,12 MB | Adobe PDF | Abrir Vista previa | |
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