Minimal-moderate variation of human oral virome and microbiome in IgA deficiency
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Título: | Minimal-moderate variation of human oral virome and microbiome in IgA deficiency |
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Autor/es: | Cruz Peña, Maria Jose de la | Gonzalez‑Granado, Luis Ignacio | Garcia-Heredia, Inmaculada | Maestre-Carballa, Lucia | Martinez-Garcia, Manuel |
Grupo/s de investigación o GITE: | Ecología Microbiana Molecular |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología |
Palabras clave: | Immunoglobulin A (IgA) | IgA deficiency | Human virome and microbiome |
Área/s de conocimiento: | Microbiología |
Fecha de publicación: | 21-jul-2021 |
Editor: | Springer Nature |
Cita bibliográfica: | Scientific Reports. 2021, 11:14913. https://doi.org/10.1038/s41598-021-94507-8 |
Resumen: | Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by ‘recognizing’ and shaping our commensal microbes. Paradoxically, yet selective IgA-deficiency is often described as asymptomatic and there is a paucity of studies only focused on the mice and human gut microbiome context fully ignoring other niches of our body and our commensal viruses. Here, we used as a model the human oral cavity and employed a holistic view and studied the impact of IgA deficiency and also common variable IgA and IgM immunodeficiencies (CVID), on both the human virome and microbiome. Unexpectedly, metagenomic and experimental data in human IgA deficiency and CVID indicate minimal-moderate changes in microbiome and virome composition compared to healthy control group and point out to a rather functional, resilient oral commensal viruses and microbes. However, a significant depletion (two fold) of bacterial cells (p-value < 0.01) and viruses was observed in IgA-deficiency. Our results demonstrate that, within the limits of our cohort, IgA role is not critical for maintaining a rather functional salivary microbiome and suggest that IgA is not a major influence on the composition of abundant commensal microbes. |
Patrocinador/es: | This work has been supported by Spanish Ministry of Economy and Competitiveness (refs. CGL2013-40564-R, RTI2018-094248-B-I00, and SAF2013-49267-EXP). |
URI: | http://hdl.handle.net/10045/116733 |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-021-94507-8 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.1038/s41598-021-94507-8 |
Aparece en las colecciones: | INV - EMM - Artículos de Revistas |
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de-la-Cruz_etal_2021_SciRep.pdf | 2,18 MB | Adobe PDF | Abrir Vista previa | |
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