Epigallocatechin Gallate Slows Retinal Degeneration, Reduces Oxidative Damage, and Modifies Circadian Rhythms in P23H Rats
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Título: | Epigallocatechin Gallate Slows Retinal Degeneration, Reduces Oxidative Damage, and Modifies Circadian Rhythms in P23H Rats |
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Autor/es: | Perdices, Lorena | Fuentes-Broto, Lorena | Segura, Francisco | Cuenca, Nicolás | Orduna, Elvira | Pinilla Lozano, Isabel |
Grupo/s de investigación o GITE: | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología |
Palabras clave: | Retinal degeneration | Retinitis pigmentosa | Visual function | Oxidative damage | Circadian rhythm | Antioxidant therapy | Epigallocatechin gallate | P23H rat | Neurodegenerative model | Green tea |
Área/s de conocimiento: | Biología Celular |
Fecha de publicación: | 8-ago-2020 |
Editor: | MDPI |
Cita bibliográfica: | Perdices L, Fuentes-Broto L, Segura F, Cuenca N, Orduna-Hospital E, Pinilla I. Epigallocatechin Gallate Slows Retinal Degeneration, Reduces Oxidative Damage, and Modifies Circadian Rhythms in P23H Rats. Antioxidants. 2020; 9(8):718. https://doi.org/10.3390/antiox9080718 |
Resumen: | Retinitis pigmentosa (RP) includes a group of genetic disorders that involve the loss of visual function due to mutations mainly in photoreceptors but also in other retinal cells. Apoptosis, retinal disorganization, and inflammation are common in the progression of the disease. Epigallocatechin gallate (EGCG) has been proved as beneficial in different eye diseases. Pigmented heterozygous P23H rat was used as an animal model of RP. Visual function was assessed by optomotor and electroretinogram (ERG) and circadian rhythms were evaluated by telemetry. Hepatic oxidative damage and antioxidant defenses were assessed using biochemical tests. The visual function of the EGCG P23H group was preserved, with a deterioration in the activity period and lower values in the interdaily stability parameter. Control rats treated with EGCG were less active than the sham group. EGCG increased antioxidant levels in P23H rats but reduced total hepatic antioxidant capacity by almost 42% in control rats compared to the sham group. We conclude that treatment with EGCG improves visual function and antioxidant status in P23H rats but diminishes antioxidant defenses in wild-type control animals, and slightly worsens activity circadian rhythms. Further studies are necessary to clarify the beneficial effects in disease conditions and in healthy organisms. |
Patrocinador/es: | This research was supported by the Spanish Ministry of Economy and Competitiveness (MINECO-FEDER BFU2015-67139-R), the Instituto de Salud Carlos III (project PI13/01124 and Ocular Pathology National Net RETICS-Oftared RETICS-FEDER RD16/0008/0016), FARPE-FUNDALUCE, ACIF/2016/055, FEDER IDIFEDER/2017/064, the Fondo Europeo de Desarrollo Regional (FEDER) funds: “Una manera de hacer Europa”, and the Government of Aragon (Group B08_17R and Predoctoral Grant L. Perdices, C060/2014). |
URI: | http://hdl.handle.net/10045/108656 |
ISSN: | 2076-3921 |
DOI: | 10.3390/antiox9080718 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.3390/antiox9080718 |
Aparece en las colecciones: | INV - NEUROVIS - Artículos de Revistas |
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