Indium-Mediated Cleavage of the Trityl Group from Protected 1H-Tetrazoles
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| Title: | Indium-Mediated Cleavage of the Trityl Group from Protected 1H-Tetrazoles |
|---|---|
| Authors: | Behloul, Cherif | Bouchelouche, Kenza | Guijarro, David | Foubelo, Francisco | Nájera, Carmen | Yus, Miguel |
| Research Group/s: | Catálisis Estereoselectiva en Síntesis Orgánica (CESO) | Síntesis Asimétrica (SINTAS) |
| Center, Department or Service: | Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica |
| Keywords: | Tetrazole | Indium | Detritylation | Cleavage |
| Knowledge Area: | Química Orgánica |
| Issue Date: | 19-Jun-2015 |
| Publisher: | Georg Thieme Verlag |
| Citation: | Synlett. 2015, 26(17): 2399-2402. doi:10.1055/s-0034-1379933 |
| Abstract: | On treatment with indium metal in MeOH–THF, trityl groups undergo reductive removal from 1H-protected tetrazoles (including aliphatic, aromatic, and heteroaromatic substituents), affording the corresponding free tetrazoles in excellent yields, without any decomposition of the tetrazole ring or reduction of any other group. |
| Sponsor: | This work was financially supported by the A.N.D.R.S (Agence Nationale pour le Développement de la Recherche en Santé) (Algérie), the Ministerio de Ciencia e Innovación of Spain (CTQ2011-24165, Consolider Ingenio 2010 CSD2007-00006), The Generalitat Valenciana (PROMETEO/2009/039, PROMETEOII/ 2014/017 and FEDER). We are very grateful to the Spanish Ministerio de Asuntos Exteriores y de Cooperación for a cooperation grant (AP/039112/11). |
| URI: | http://hdl.handle.net/10045/58133 |
| ISSN: | 0936-5214 (Print) | 1437-2096 (Online) |
| DOI: | 10.1055/s-0034-1379933 |
| Language: | eng |
| Type: | info:eu-repo/semantics/article |
| Rights: | © Georg Thieme Verlag Stuttgart · New York |
| Peer Review: | si |
| Publisher version: | http://dx.doi.org/10.1055/s-0034-1379933 |
| Appears in Collections: | INV - CESO - Artículos de Revistas INV - SINTAS - Artículos de Revistas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
 2015_Behloul_etal_Synlett_final.pdf | Versión final (acceso restringido) | 156,12 kB | Adobe PDF | Open Request a copy |
 2015_Behloul_etal_Synlett_rev.pdf | Versión revisada (acceso abierto) | 207,18 kB | Adobe PDF | Open Preview |
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