Role of IFN-gamma in immune responses to Candida albicans infections
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10045/47685
Title: | Role of IFN-gamma in immune responses to Candida albicans infections |
---|---|
Authors: | Gozalbo, Daniel | Maneu, Victoria | Gil, María Luisa |
Research Group/s: | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) |
Center, Department or Service: | Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía |
Keywords: | Candida albicans | Candidiasis | Infection | IFN-gamma | Review |
Knowledge Area: | Farmacología |
Issue Date: | 1-Jun-2014 |
Publisher: | Frontiers in Bioscience |
Citation: | Frontiers in Bioscience (Landmark Ed.). 2014, 19: 1279-1290. doi:10.2741/4281 |
Abstract: | Candida albicans is the most frequent etiologic agent that causes opportunistic fungal infections called candidiasis, a disease whose systemic manifestation could prove fatal and whose incidence is increasing as a result of an expanding immunocompromised population. Here we review the role of interferon-gamma (IFN-γ) in host protection against invasive candidiasis. This cytokine plays an essential role in both the innate and adaptive arms of the immune response to candidiasis. We focus on recent progress on host-pathogen interactions leading to the production of IFN-γ by host cells. IFN-γ is produced by CD4 Th1, CD8, γδ T, and natural killer (NK) cells, essentially in response to both IL-12 and/or IL-18; more recently, a subset of C. albicans-specific Th17 cells have been described to produce both IL-17 and IFN-γ. IFN-γ plays an important role in the regulation of the immune system as well as in the control of the infectious process, as it is required for optimal activation of phagocytes, collaborates in the generation of protective antibody response, and favors the development of a Th1 protective response. |
Sponsor: | Research in the M.L. Gil and D. Gozalbo laboratory is supported by Grant SAF2010-18256 (Ministerio de Economia y Competitividad, Spain). |
URI: | http://hdl.handle.net/10045/47685 |
ISSN: | 1093-9946 (Print) | 1093-4715 (Online) |
DOI: | 10.2741/4281 |
Language: | eng |
Type: | info:eu-repo/semantics/article |
Rights: | © 2014 Frontiers in Bioscience |
Peer Review: | si |
Publisher version: | http://dx.doi.org/10.2741/4281 |
Appears in Collections: | INV - NEUROVIS - Artículos de Revistas |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
2014_Gozalbo_etal_ Frontiers-in-Bioscience.pdf | Versión revisada (acceso abierto) | 198,76 kB | Adobe PDF | Open Preview |
Items in RUA are protected by copyright, with all rights reserved, unless otherwise indicated.