The pancreatic β-cell in ageing: Implications in age-related diabetes
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http://hdl.handle.net/10045/126200
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DC Field | Value | Language |
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dc.contributor | Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS) | es_ES |
dc.contributor | Fisiología Neuroendocrina (FINE) | es_ES |
dc.contributor.author | Tudurí, Eva | - |
dc.contributor.author | Soriano, Sergi | - |
dc.contributor.author | Almagro, Lucía | - |
dc.contributor.author | Montanya, Eduard | - |
dc.contributor.author | Alonso Magdalena, Paloma | - |
dc.contributor.author | Nadal, Ángel | - |
dc.contributor.author | Quesada, Iván | - |
dc.contributor.other | Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | es_ES |
dc.date.accessioned | 2022-08-29T11:20:16Z | - |
dc.date.available | 2022-08-29T11:20:16Z | - |
dc.date.issued | 2022-06-17 | - |
dc.identifier.citation | Ageing Research Reviews. 2022, 80: 101674. https://doi.org/10.1016/j.arr.2022.101674 | es_ES |
dc.identifier.issn | 1568-1637 (Print) | - |
dc.identifier.issn | 1872-9649 (Online) | - |
dc.identifier.uri | http://hdl.handle.net/10045/126200 | - |
dc.description.abstract | The prevalence of type 2 diabetes (T2D) and impaired glucose tolerance (IGT) increases with ageing. T2D generally results from progressive impairment of the pancreatic islets to adapt β-cell mass and function in the setting of insulin resistance and increased insulin demand. Several studies have shown an age-related decline in peripheral insulin sensitivity. However, a precise understanding of the pancreatic β-cell response in ageing is still lacking. In this review, we summarize the age-related alterations, adaptations and/or failures of β-cells at the molecular, morphological and functional levels in mouse and human. Age-associated alterations include processes such as β-cell proliferation, apoptosis and cell identity that can influence β-cell mass. Age-related changes also affect β-cell function at distinct steps including electrical activity, Ca2+ signaling and insulin secretion, among others. We will consider the potential impact of these alterations and those mediated by senescence pathways on β-cells and their implications in age-related T2D. Finally, given the great diversity of results in the field of β-cell ageing, we will discuss the sources of this heterogeneity. A better understanding of β-cell biology during ageing, particularly at older ages, will improve our insight into the contribution of β-cells to age-associated T2D and may boost new therapeutic strategies. | es_ES |
dc.description.sponsorship | This research was supported by grants from the Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación, Fondo Europeo de Desarrollo Regional (FEDER), Instituto de Salud Carlos III and Generalitat Valenciana: PID2020-117294RB-I00 and PROMETEO/2020/006 to AN, BFU2016-77125-R to IQ, PID2020-113112RB-I00 to PAM and PI19/00246 to EM. CIBERDEM is an initiative of the Instituto de Salud Carlos III. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | © 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.subject | Ageing | es_ES |
dc.subject | Insulin secretion | es_ES |
dc.subject | Pancreatic beta-cell function | es_ES |
dc.subject | Pancreatic beta-cell mass | es_ES |
dc.subject | Senescence | es_ES |
dc.subject | Diabetes | es_ES |
dc.title | The pancreatic β-cell in ageing: Implications in age-related diabetes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.peerreviewed | si | es_ES |
dc.identifier.doi | 10.1016/j.arr.2022.101674 | - |
dc.relation.publisherversion | https://doi.org/10.1016/j.arr.2022.101674 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117294RB-I00 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-77125-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113112RB-I00 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//PI19%2F00246 | es_ES |
Appears in Collections: | INV - FINE - Artículos de Revistas INV - NEUROVIS - Artículos de Revistas |
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File | Description | Size | Format | |
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Tuduri_etal_2022_AgeingResRev.pdf | 1,65 MB | Adobe PDF | Open Preview | |
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