López, Tessy, Manrique-Arias, Juan C., Ramírez, Paola, Larraza, Pamela, Rodríguez Reinoso, Francisco
Radio Pet Therapy of Healthy Wistar Rats with 64CuCl2 Labeled to 64Cu(AcAc)2 Supported in Functionalized TiO2 Nanoparticles
Journal of Encapsulation and Adsorption Sciences. 2017, 7(3): Article ID:79316, 6 pages. doi:10.4236/jeas.2017.73009
URI: http://hdl.handle.net/10045/88627
DOI: 10.4236/jeas.2017.73009
ISSN: 2161-4865 (Print)
Abstract: 
In recent years Copper-64 in the chemical form of copper chloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy. The aim of this research was to determine the biodistribution and the labeling of radio nanoparticle with 64CuCl2, the nanoparticles Cu(acac)2/F-TiO2 were mixed with 64CuCl2 (20-37 MBq), then the final solution was used to injected healthy Wistar rats to probe the absorption of nanoparticle inside tissue trough of the groups OH that are formed during the functionalization of the Cu(acac)2/F-TiO2. The “in vivo” evaluation after realize the images study in micro PET equipment, uptake of the radio-nanoparticle was observed in the digestive system in the healthy Wistar rats.
Keywords:PET Therapy, Nanoparticles, Functionalized Titania (F-Tio2), Titanium Acetylacetonate [Cu (AcAc)2], Cu(Acac)2/F-Tio2, PET Lesion Detection, Imaging
Scientific Research Publishing
info:eu-repo/semantics/article