Alonso, Francisco, Moglie, Yanina, Radivoy, Gabriel, Yus, Miguel
Alkenes as Azido Precursors for the One-Pot Synthesis of 1,2,3-Triazoles Catalyzed by Copper Nanoparticles on Activated Carbon
ALONSO, Francisco, et al. “Alkenes as Azido Precursors for the One-Pot Synthesis of 1,2,3-Triazoles Catalyzed by Copper Nanoparticles on Activated Carbon”. Journal of Organic Chemistry. Vol. 78, No. 10 (2013). ISSN 0022-3263, pp. 5031-5037
URI: http://hdl.handle.net/10045/28456
DOI: 10.1021/jo400110m
ISSN: 0022-3263 (Print)
Abstract: 
A one-pot protocol for the synthesis of 1,2,3-triazoles has been developed starting from inactivated alkenes and based on two click reactions: the azidosulfenylation of the carbon–carbon double bond and the copper-catalyzed azide–alkyne cycloaddition (CuAAC). High yields of the β-methylsulfanyl triazoles have been attained using CuNPs/C as catalyst, with other commercial copper catalysts being completely inactive. The versatility of the methylsulfanyl group has been demonstrated through a series of synthetic transformations, including direct access to 1-vinyl and 4-monosubstituted triazoles.
Keywords:Alkenes, Nanoparticles
American Chemical Society
info:eu-repo/semantics/article