Guillena, Gabriela, Ramón, Diego J.
Enantioselective α-heterofunctionalisation of carbonyl compounds: organocatalysis is the simplest approach
GUILLENA TOWNLEY, Gabriela; RAMÓN DANGLA, Diego José. "Enantioselective α-heterofunctionalisation of carbonyl compounds: organocatalysis is the simplest approach". Tetrahedron: Asymmetry. Vol. 17, Issue 10 (19 June 2006). ISSN 0957-4166, pp. 1465-1492
URI: http://hdl.handle.net/10045/2475
DOI: 10.1016/j.tetasy.2006.05.020
ISSN: 0957-4166
Abstract: 
Enantioselective organocatalytic processes have reached maturity in recent years with an impressive number of applications now available. The application of these advantageous methodologies to the construction of chiral α-hetereofunctionalised carbonyl compounds allows us to obtain important chiral building blocks, such as α-amino acids, α-amino alcohols, aziridines, epoxides, 1,2-diols and α-sulfenylated, selenenylated and halogenated carbonyl derivatives. Proline, imidazolidinone derivatives, cinchona alkaloids and their ammonium salts, as well as Brønsted acid derivatives, have been used as chiral catalysts for these purposes. A survey of contributions in this field will be discussed throughout this review.
Keywords:Organocatalysis, Heterofunctionalisation, Enantioselective, Asymmetric synthesis, α-carbonyl compounds, Proline
Elsevier
info:eu-repo/semantics/article