Alonso, Diego A., Maciá Ruiz, Beatriz, Pastor, Isidro M., Baeza, Alejandro
Recent Advances on the Catalytic Asymmetric Allylic α‑Alkylation of Carbonyl Derivatives Using Free Allylic Alcohols
ACS Organic & Inorganic Au. 2024. https://doi.org/10.1021/acsorginorgau.3c00065
URI: http://hdl.handle.net/10045/140750
DOI: 10.1021/acsorginorgau.3c00065
ISSN: 2694-247X
Abstract: 
During the last years, the development of more sustainable and straightforward methodologies to minimize the generation of waste organic substances has acquired high importance within synthetic organic chemistry. Therefore, it is not surprising that many efforts are devoted to ameliorating already well-known successful methodologies, that is, the case of the asymmetric allylic allylation reaction of carbonyl compounds. The use of free alcohols as alkylating agents in this transformation represents a step forward in this sense since it minimizes waste production and the substrate manipulation. In this review, we aim to gather the most recent methodologies describing this strategy by paying special attention to the reaction mechanisms, as well as their synthetic applications.
Keywords:Asymmetric catalysis, Allylic alcohols, Carbonyl compounds, Allylic alkylation, Green chemistry, Organocatalysis, Metal catalysis, Natural products
American Chemical Society
info:eu-repo/semantics/article