Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties

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dc.contributorSíntesis Asimétrica (SINTAS)es_ES
dc.contributor.authorBelveren, Samet-
dc.contributor.authorPoyraz, Samet-
dc.contributor.authorPask, Christopher M.-
dc.contributor.authorÜlger, Mahmut-
dc.contributor.authorSansano, Jose M.-
dc.contributor.authorDondas, H. Ali-
dc.contributor.otherUniversidad de Alicante. Departamento de Química Orgánicaes_ES
dc.contributor.otherUniversidad de Alicante. Instituto Universitario de Síntesis Orgánicaes_ES
dc.identifier.citationInorganica Chimica Acta. 2019, 498: 119154. doi:10.1016/j.ica.2019.119154es_ES
dc.identifier.issn0020-1693 (Print)-
dc.identifier.issn1873-3255 (Online)-
dc.description.abstractPlatinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)° and trans-bond angles of 176.19(6) and 177.08(6)°, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols.es_ES
dc.description.sponsorshipThis work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). We gratefully acknowledge financial support from Mersin University and the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), University of Alicante and Mersin University (Project. MEU-2017-COL-01007-M150D).es_ES
dc.rights© 2019 Elsevier B.V.es_ES
dc.subjectPlatinum complexeses_ES
dc.subject.otherQuímica Orgánicaes_ES
dc.titleSynthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moietieses_ES
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