Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties

Please use this identifier to cite or link to this item: http://hdl.handle.net/10045/96887
Información del item - Informació de l'item - Item information
Title: Synthesis and biological evaluation of platinum complexes of highly functionalized aroylaminocarbo-N-thioyl prolinate containing tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione moieties
Authors: Belveren, Samet | Poyraz, Samet | Pask, Christopher M. | Ülger, Mahmut | Sansano, Jose M. | Dondas, H. Ali
Research Group/s: Síntesis Asimétrica (SINTAS)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: Platinum complexes | Aminocarbothiol | Antibacterial | Antifungal
Knowledge Area: Química Orgánica
Issue Date: 1-Dec-2019
Publisher: Elsevier
Citation: Inorganica Chimica Acta. 2019, 498: 119154. doi:10.1016/j.ica.2019.119154
Abstract: Platinum complexes, derived from two families of bidentate funcionalized aroylaminocarbo-N-thyoyl prolinates, are prepared using mild conditions from prolinates, which are available via 1,3-dipolar cycloadditions. The resulting four coordinated neutral square-planar platinum(II) complexes are very stable and are fully characterized. Their structures are determined by spectroscopic and analytical methods and one of them by single crystal X-ray diffraction analysis. In this pattern, the platinum exhibits distorted square planar geometry, with cis-bond angles ranging from 89.42(2) and 94.37(6)° and trans-bond angles of 176.19(6) and 177.08(6)°, respectively. Anti(myco)bacterial and antifungal studies of all these new compounds are carried out under standardized protocols.
Sponsor: This work is a part of Samet Belveren's ongoing PhD thesis granted by Mersin University (Project no. BAP-SBE TEB(SB) 2017-2-TP3-2564). We gratefully acknowledge financial support from Mersin University and the Spanish Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P and CTQ2014-51912-REDC), the Spanish Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER, EU) (projects CTQ2016-76782-P and CTQ2016-81797-REDC), the Generalitat Valenciana (PROMETEOII/2014/017), University of Alicante and Mersin University (Project. MEU-2017-COL-01007-M150D).
URI: http://hdl.handle.net/10045/96887
ISSN: 0020-1693 (Print) | 1873-3255 (Online)
DOI: 10.1016/j.ica.2019.119154
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2019 Elsevier B.V.
Peer Review: si
Publisher version: https://doi.org/10.1016/j.ica.2019.119154
Appears in Collections:INV - SINTAS - Artículos de Revistas

Files in This Item:
Files in This Item:
File Description SizeFormat 
Thumbnail2019_Belveren_etal_InorganicaChimicaActa_final.pdfVersión final (acceso restringido)1 MBAdobe PDFOpen    Request a copy
Thumbnail2019_Belveren_etal_InorganicaChimicaActa_revised.pdfEmbargo 24 meses (acceso abierto: 13 sept. 2021)1,34 MBAdobe PDFOpen    Request a copy


Items in RUA are protected by copyright, with all rights reserved, unless otherwise indicated.