Radio Pet Therapy of Healthy Wistar Rats with 64CuCl2 Labeled to 64Cu(AcAc)2 Supported in Functionalized TiO2 Nanoparticles
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Título: | Radio Pet Therapy of Healthy Wistar Rats with 64CuCl2 Labeled to 64Cu(AcAc)2 Supported in Functionalized TiO2 Nanoparticles |
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Autor/es: | López, Tessy | Manrique-Arias, Juan C. | Ramírez, Paola | Larraza, Pamela | Rodríguez Reinoso, Francisco |
Grupo/s de investigación o GITE: | Materiales Avanzados |
Centro, Departamento o Servicio: | Universidad de Alicante. Departamento de Química Inorgánica |
Palabras clave: | PET Therapy | Nanoparticles | Functionalized Titania (F-Tio2) | Titanium Acetylacetonate [Cu (AcAc)2] | Cu(Acac)2/F-Tio2 | PET Lesion Detection | Imaging |
Área/s de conocimiento: | Química Inorgánica |
Fecha de publicación: | 26-sep-2017 |
Editor: | Scientific Research Publishing |
Cita bibliográfica: | Journal of Encapsulation and Adsorption Sciences. 2017, 7(3): Article ID:79316, 6 pages. doi:10.4236/jeas.2017.73009 |
Resumen: | In recent years Copper-64 in the chemical form of copper chloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy. The aim of this research was to determine the biodistribution and the labeling of radio nanoparticle with 64CuCl2, the nanoparticles Cu(acac)2/F-TiO2 were mixed with 64CuCl2 (20-37 MBq), then the final solution was used to injected healthy Wistar rats to probe the absorption of nanoparticle inside tissue trough of the groups OH that are formed during the functionalization of the Cu(acac)2/F-TiO2. The “in vivo” evaluation after realize the images study in micro PET equipment, uptake of the radio-nanoparticle was observed in the digestive system in the healthy Wistar rats. |
URI: | http://hdl.handle.net/10045/88627 |
ISSN: | 2161-4865 (Print) | 2161-4873 (Online) |
DOI: | 10.4236/jeas.2017.73009 |
Idioma: | eng |
Tipo: | info:eu-repo/semantics/article |
Derechos: | © 2017 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ |
Revisión científica: | si |
Versión del editor: | https://doi.org/10.4236/jeas.2017.73009 |
Aparece en las colecciones: | INV - LMA - Artículos de Revistas |
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