Association between perceived level of stress, clinical characteristics and psychopathological symptoms in women with systemic lupus erythematosus

Please use this identifier to cite or link to this item: http://hdl.handle.net/10045/77161
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Title: Association between perceived level of stress, clinical characteristics and psychopathological symptoms in women with systemic lupus erythematosus
Authors: Peralta-Ramírez, María Isabel | Pérez-Mármol, José Manuel | Castañeda-Cabestany, Margarita | Santos-Ruiz, Ana | Montero-López, Eva | Callejas-Rubio, José Luis | Navarrete-Navarrete, Nuria | Fernández-Sánchez, José Carlos | Jiménez-Alonso, Juan Francisco | Ortego-Centeno, Norberto | Sabio, José Mario | García-Morales, Marta
Research Group/s: Calidad de Vida, Bienestar Psicológico y Salud | Psicología Aplicada a la Salud y Comportamiento Humano (PSYBHE)
Center, Department or Service: Universidad de Alicante. Departamento de Psicología de la Salud
Keywords: Systemic lupus erythematosus | Psychological stress | Risk factors | Psychopathology
Knowledge Area: Psicología Básica
Issue Date: 17-May-2018
Publisher: Clinical and Experimental Rheumatology
Citation: Clinical and Experimental Rheumatology. 2018, 36(3): 434-441
Abstract: Objective: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. Methods: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36.61 (10.15), and 223 healthy women, with age-matched controls. The assessment included the clinical characteristics (disease duration, SLE activity, cumulative organ damage, pharmacotherapy), the Symptom Checklist-90-Revised (SCL-90-R) and the Perceived Stress Scale. Descriptive, comparative, univariate and multivariate analysis were performed. Results: SLE patients showed psychopathological alterations in the somatisation, obsessive-compulsive and positive discomfort subscales of SCL-90-R. Women with SLE reported significantly higher scores on the psychopathological dimensions and perceived stress compared to healthy women, except for paranoid ideation. Disease duration, SLE activity, cumulative organ damage, and perceived stress were shown to be significant predictors of psychopathological manifestations, explaining a range, between 20 and 43%, of variance across SCL-90-R dimensions. Moreover, perceived stress was related to SLE activity, after controlling for psychopathological dimensions. Conclusion: The psychopathological manifestations in SLE appeared to be influenced by perceived stress, disease duration, disease activity and cumulative organ damage. In turn, perceived stress was associated with disease severity. This knowledge may contribute to a more comprehensive perspective of these manifestations in the SLE population in the clinical setting.
Sponsor: This research was developed in the framework of the I+D Project “SEJ2007-61857” and the I+D Project ‘‘PSI2010- 15780’’, funded by the Spanish Ministry of Education and Science. In addition, this study was supported by the Andalusian Health Service (grant no. PI-0059/2007).
URI: http://hdl.handle.net/10045/77161
ISSN: 0392-856X (Print) | 1593-098X (Online)
Language: eng
Type: info:eu-repo/semantics/article
Rights: © Clinical and Experimental Rheumatology
Peer Review: si
Publisher version: http://www.clinexprheumatol.org/abstract.asp?a=11530
Appears in Collections:INV - CV, BP Y S - Artículos de Revistas
INV - PSYBHE - Artículos de Revistas

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