Aronia–citrus juice (polyphenol-rich juice) intake and elite triathlon training: a lipidomic approach using representative oxylipins in urine

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Title: Aronia–citrus juice (polyphenol-rich juice) intake and elite triathlon training: a lipidomic approach using representative oxylipins in urine
Authors: García-Flores, Libia Alejandra | Medina, Sonia | Gómez, Cristina | Wheelock, Craig E. | Cejuela Anta, Roberto | Martínez Sanz, José Miguel | Oger, Camille | Galano, Jean-Marie | Durand, Thierry | Hernández-Sáez, Álvaro | Ferreres, Federico | Gil-Izquierdo, Ángel
Research Group/s: Research in Physical Education, Fitness and Performance (RIPEFAP) | Grupo de Investigación en Alimentación y Nutrición (ALINUT)
Center, Department or Service: Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas | Universidad de Alicante. Departamento de Enfermería
Keywords: Urinary oxylipins | Polyphenols | Juice | Athletes | Training
Knowledge Area: Educación Física y Deportiva | Enfermería
Issue Date: 22-Nov-2017
Publisher: Royal Society of Chemistry
Citation: Food & Function. 2018, 9: 463-475. doi:10.1039/C7FO01409K
Abstract: In the present study, we examined whether particular urinary oxylipins (isoprostanes (IsoPs), leukotrienes (LTs), prostaglandins (PGs), and thromboxanes (TXs)) in 16 elite triathletes could alter during 145 days of training. Within this time span, 45 days were dedicated to examining the effects of the intake of a beverage rich in polyphenols (one serving: 200 mL per day) supplemented in their diet. The beverage was a mixture of citrus juice (95%) and Aronia melanocarpa juice (5%) (ACJ). Fifty-two oxylipins were analyzed in the urine. The quantification was carried out using solid-phase extraction, liquid chromatography coupled with triple quadrupole mass spectrometry. The physical activity decreased the excretion of some PG, IsoP, TX, and LT metabolites from arachidonic acid, γ-dihomo-linolenic acid, and eicosapentaenoic acid. The ACJ also reduced the excretion of 2,3-dinor-11β-PGF2α and 11-dehydro-TXB2, although the levels of other metabolites increased after juice supplementation (PGE2, 15-keto-15-F2t-IsoP, 20-OH-PGE2, LTE4, and 15-epi-15-E2t-IsoP), compared to the placebo. The metabolites that increased in abundance have been related to vascular homeostasis and smooth muscle function, suggesting a positive effect on the cardiovascular system. In conclusion, exercise influences mainly the decrease in oxidative stress and the inflammation status in elite triathletes, while ACJ supplementation has a potential benefit regarding the cardiovascular system that is connected in a synergistic manner with elite physical activity.
Sponsor: This study was supported by the Project AGL2011-23690 (CICYT) (Spanish Ministry of Economy and Competitiveness). This work was partially funded by the “Fundación Séneca de la Región de Murcia” Grupo de Excelencia 19900/GERM/15. This work is included in the framework of the collaboration between the Spanish Research Council (CEBAS-CSIC) and CNRS-University of Montpellier as “Projets Internationaux de Cooperation Scientifique” (PICS-2015-261141). LAGF was granted a pre-doctoral FPI fellowship by the Spanish government as well as a scholarship that allowed the collaboration with Dr Craig Wheelock’s group (Department of Medical Biochemistry and Biophysics (MBB)) at the Karolinska Institute. The authors are also grateful to the University of Alicante for its collaboration. Sonia Medina was appointed under a research contract from the Project AGL2011-23690 (CICYT).
ISSN: 2042-6496 (Print) | 2042-650X (Online)
DOI: 10.1039/C7FO01409K
Language: eng
Type: info:eu-repo/semantics/article
Rights: © The Royal Society of Chemistry 2018
Peer Review: si
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Appears in Collections:INV - RIPEFAP - Artículos de Revistas
INV - ALINUT - Artículos de Revistas

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