Organocatalyzed Assembly of Chlorinated Quaternary Stereogenic Centers

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Title: Organocatalyzed Assembly of Chlorinated Quaternary Stereogenic Centers
Authors: Gómez-Martínez, Melania | Alonso, Diego A. | Pastor, Isidro M. | Guillena, Gabriela | Baeza, Alejandro
Research Group/s: Catálisis Estereoselectiva en Síntesis Orgánica (CESO) | Nuevos Materiales y Catalizadores (MATCAT)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: Asymmetric catalysis | Carbonyl compounds | Chlorine | Organocatalysis | Quaternary stereocenters
Knowledge Area: Química Orgánica
Issue Date: Dec-2016
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
Citation: Asian Journal of Organic Chemistry. 2016, 5(12): 1428-1437. doi:10.1002/ajoc.201600404
Abstract: The catalytic asymmetric construction of chiral quaternary stereocenters is a continual area of research for organic chemists. In this sense, when a chlorine atom is introduced to a quaternary stereocenter, the synthetic difficulty of the resulting molecule increases along with its significance. This is true not only because of the intrinsic interest in such chlorinated molecules but also because they are highly valuable chiral building blocks in organic synthesis, as they can be converted into more complex molecules by a SN2 displacement reaction. Among the different strategies to create chlorinated quaternary stereogenic centers, organocatalysis has played a pivotal role over the past decade. In this review, a comprehensive analysis of such organocatalyzed transformations with a focus on the α-chlorination of carbonyl compounds is presented.
Sponsor: Financial support from the University of Alicante (VIGROB-173) and the Spanish Ministerio de Economía y Competitividad (CTQ2015-66624-P) is acknowledged.
ISSN: 2193-5807 (Print) | 2193-5815 (Online)
DOI: 10.1002/ajoc.201600404
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Peer Review: si
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Appears in Collections:INV - CESO - Artículos de Revistas
INV - MATCAT - Artículos de Revistas
INV - AMIC - Artículos de Revistas

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