The effects of corticosteroids on cognitive flexibility and decision-making in women with lupus

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Title: The effects of corticosteroids on cognitive flexibility and decision-making in women with lupus
Authors: Montero-López, Eva | Santos-Ruiz, Ana | Navarrete-Navarrete, Nuria | Ortego-Centeno, Norberto | Pérez-García, Miguel | Peralta-Ramírez, María Isabel
Research Group/s: Calidad de Vida, Bienestar Psicológico y Salud | Psicología de la Delincuencia, Psicocriminología y Ciencias Forenses (PSIDECRIMYCIF)
Center, Department or Service: Universidad de Alicante. Departamento de Psicología de la Salud
Keywords: Corticosteroids | Executive function | Flexibility | Decision-making | Systemic lupus erythematosus (SLE)
Knowledge Area: Psicología Básica
Issue Date: 6-Apr-2016
Publisher: SAGE Publications
Citation: Lupus. 2016, 25(13): 1470-1478. doi:10.1177/0961203316642313
Abstract: The aim of this study was to investigate the possible effects of corticosteroids in women with systemic lupus erythematosus (SLE) in two processes of executive function: cognitive flexibility and decision-making. To that end, we evaluated 121 women divided into three groups: 50 healthy women, 38 women with SLE not receiving corticosteroid treatment and 33 women with SLE receiving corticosteroid treatment. Cognitive flexibility was measured with the Trail Making Tests A and B; decision-making was measured with the Iowa Gambling Task. Additionally, demographic (age and education level), clinical (SLE Disease Activity Index (SLEDAI), Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) and disease duration) and psychological characteristics (stress vulnerability, perceived stress and psychopathic symptomatology) were evaluated. The results showed that both SLE groups displayed poorer decision-making than the healthy women (p = 0.006) and also that the SLE group receiving corticosteroid treatment showed lower cognitive flexibility than the other two groups (p = 0.030). Moreover, SLE patients showed poorer scores than healthy women on the following SCL-90-R subscales: somatisation (p = 0.005), obsessions and compulsions (p = 0.045), depression (p = 0.004), hostility (p = 0.013), phobic anxiety (p = 0.005), psychoticism (p = 0.016) and positive symptom total (p = 0.001). In addition, both SLE groups were more vulnerable to stress (p = 0.000). These findings help to understand the effects of corticosteroid treatment on cognitive flexibility and decision-making, in addition to the disease-specific effects suffered by women with SLE.
Sponsor: This study is a part of a doctoral thesis, and was supported by the I+D Project “PSI2010-15780” of the Spanish Ministry of Science and Innovation.
ISSN: 0961-2033 (Print) | 1477-0962 (Online)
DOI: 10.1177/0961203316642313
Language: eng
Type: info:eu-repo/semantics/article
Rights: © The Author(s), 2016
Peer Review: si
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Appears in Collections:INV - PSYBHE - Artículos de Revistas
INV - CV, BP Y S - Artículos de Revistas

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