DNA catabolites in triathletes: effects of supplementation with an aronia–citrus juice (polyphenols-rich juice)

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Title: DNA catabolites in triathletes: effects of supplementation with an aronia–citrus juice (polyphenols-rich juice)
Authors: García-Flores, Libia A. | Medina, Sonia | Cejuela Anta, Roberto | Martínez Sanz, José Miguel | Abellán, Ángel | Genieser, Hans-Gottfried | Ferreres, Federico | Gil-Izquierdo, Ángel
Research Group/s: Grupo de Investigación en Ciencias de la Actividad Física y el Deporte (GICAFD) | Grupo de Investigación en Alimentación y Nutrición (ALINUT)
Center, Department or Service: Universidad de Alicante. Departamento de Didáctica General y Didácticas Específicas | Universidad de Alicante. Departamento de Enfermería
Keywords: Oxidative stress | DNA catabolites | Physical exercise | Juice intake | Citrus and Aronia melanocarpa
Knowledge Area: Educación Física y Deportiva | Enfermería
Issue Date: 17-Mar-2016
Publisher: Royal Society of Chemistry
Citation: Food & Function. 2016, 7: 2084-2093. doi:10.1039/c6fo00252h
Abstract: In this study we analyzed whether our aronia–citrus juice (ACJ, the composition is based on a mixture of 95% citrus juice with 5% of Aronia melanocarpa juice), rich in polyphenols, and physical exercise had an effect on seven catabolites of DNA identified in plasma and on a urine isoprostane (8-iso-PGF2α). Sixteen elite triathletes on a controlled diet for triathlon training (45 days) were used in this clinical trial. Our results show a decrease in the 8-hydroxy-2′-deoxyguanosine concentration due to chronic physical exercise. The ACJ intake and physical exercise maintained the guanosine-3′,5′-cyclic monophosphate plasmatic concentrations and decreased the concentration of 8-hydroxyguanine as well as urinary values of 8-iso-PGF2α. Finally, we observed a significant increase in the 8-nitroguanosine levels in triathletes after ACJ intake, compared to the placebo stage. It is concluded that the combination of the intake of ACJ, rich in polyphenolic compounds, with adequate training was able to influence the plasmatic and urinary values of oxidative stress biomarkers. This suggests a positive effect on the oxidative damage and potential associations with DNA repair mechanisms.
Sponsor: LAGF was awarded a pre-doctoral FPI fellowship (BES2012-060185) by the Spanish government. This study was supported by the project AGL2011-23690 (CICYT) (Spanish Ministry of Economy and Competitiveness). This work has been partially funded by the “Fundación Séneca de la Región de Murcia” Grupo de Excelencia 19900/GERM/15.
URI: http://hdl.handle.net/10045/54330
ISSN: 2042-6496 (Print) | 2042-650X (Online)
DOI: 10.1039/c6fo00252h
Language: eng
Type: info:eu-repo/semantics/article
Rights: © Royal Society of Chemistry 2016
Peer Review: si
Publisher version: http://dx.doi.org/10.1039/c6fo00252h
Appears in Collections:INV - GICAFD - Artículos de Revistas
INV - ALINUT - Artículos de Revistas
INV - RIPEFAP - Artículos de Revistas

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