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Capacitation and acrosome reaction changes α-tubulin immunodistribution in human spermatozoa

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10045/46906
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Campo DCValorIdioma
dc.contributorBiotecnologíaes
dc.contributor.authorFrancou, María Manuela-
dc.contributor.authorTen Morro, Jorge-
dc.contributor.authorBernabeu, Rafael-
dc.contributor.authorJuan Herrero, Joaquín de-
dc.contributor.otherUniversidad de Alicante. Departamento de Biotecnologíaes
dc.date.accessioned2015-05-20T12:57:14Z-
dc.date.available2015-05-20T12:57:14Z-
dc.date.issued2014-02-
dc.identifier.citationReproductive BioMedicine Online. 2014, 28(2): 246-250. doi:10.1016/j.rbmo.2013.10.001es
dc.identifier.issn1472-6483 (Print)-
dc.identifier.issn1472-6491 (Online)-
dc.identifier.urihttp://hdl.handle.net/10045/46906-
dc.description.abstractTubulin is a protein constituent of cytoskeletal microtubules, closely related to sperm motility. However, the changes in tubulin distribution following capacitation and acrosome reaction are poorly understood. This study immunolocalized and quantified the expression of α-tubulin in fresh, capacitated and acrosome-reacted samples. Immunocytochemical data showed that in capacitated and acrosome-reacted spermatozoa, α-tubulin is labelled throughout most of the flagellum (⩾66.66%). However, the mean α-tubulin-labelled area in these samples was significantly lower than in fresh samples (P < 0.05). Thus, there are different sperm clusters distinguished by their α-tubulin immunoreactivity and this could be directly linked to structural changes following capacitation and acrosome reaction.es
dc.description.sponsorshipThis project was supported by the Cátedra de Medicina de la Reproducción, Alicante University-Instituto Bernabeu, Grant 4–12I to JDJ, as well as the Vicerrectorado de Innovación, University of Alicante, Spain, Grant Vigrob-137 to JDJ.es
dc.languageenges
dc.publisherElsevieres
dc.rights© 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd.es
dc.subjectAcrosome reactiones
dc.subjectCapacitationes
dc.subjectCytoskeletones
dc.subjectImmunocytochemistryes
dc.subjectSpermatozoaes
dc.subjectTubulines
dc.subject.otherBiología Celulares
dc.titleCapacitation and acrosome reaction changes α-tubulin immunodistribution in human spermatozoaes
dc.typeinfo:eu-repo/semantics/articlees
dc.peerreviewedsies
dc.identifier.doi10.1016/j.rbmo.2013.10.001-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.rbmo.2013.10.001es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccesses
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