Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects

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Title: Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson's disease subjects
Authors: Beach, Thomas G. | Carew, Jeremiah | Serrano, Geidy | Adler, Charles H. | Shill, Holly A. | Sue, Lucia I. | Sabbagh, Marwan N. | Akiyama, Haruhiko | Cuenca, Nicolás | The Arizona Parkinson's Disease Consortium
Research Group/s: Neurobiología del Sistema Visual y Terapia de Enfermedades Neurodegenerativas (NEUROVIS)
Center, Department or Service: Universidad de Alicante. Departamento de Fisiología, Genética y Microbiología | Universidad de Alicante. Instituto Multidisciplinar para el Estudio del Medio "Ramón Margalef"
Keywords: Lewy body | Pathology | Autopsy | Diagnosis | Melanopsin | Ganglion cell
Knowledge Area: Biología Celular
Issue Date: 13-Jun-2014
Publisher: Elsevier
Citation: Neuroscience Letters. 2014, 571: 34-38. doi:10.1016/j.neulet.2014.04.027
Abstract: Visual symptoms are relatively common in Parkinson's disease (PD) and optical coherence tomography has indicated possible retinal thinning. Accumulation of aggregated α-synuclein is thought to be a central pathogenic event in the PD brain but there have not as yet been reports of retinal synucleinopathy. Retinal wholemounts were prepared from subjects with a primary clinicopathological diagnosis of PD (N = 9), dementia with Lewy bodies (DLB; N = 3), Alzheimer's disease (N = 3), progressive supranuclear palsy (N = 2) as well as elderly normal control subjects (N = 4). These were immunohistochemically stained with an antibody against α-synuclein phosphorylated at serine 129, which is a specific molecular marker of synucleinopathy. Phosphorylated α-synuclein-immunoreactive (p-syn IR) nerve fibers were present in 7/9 PD subjects and in 1/3 DLB subjects; these were sparsely distributed and superficially located near or at the inner retinal surface. The fibers were either long and straight or branching, often with multiple en-passant varicosities along their length. The straight fibers most often had an orientation that was radial with respect to the optic disk. Together, these features are suggestive of either retinopetal/centrifugal fibers or of ganglion cell axons. In one PD subject there were sparse p-syn IR neuronal cell bodies with dendritic morphology suggestive of G19 retinal ganglion cells or intrinsically photosensitive ganglion cells. There were no stained nerve fibers or other specific staining in any of the non-PD or non-DLB subjects. It is possible that at least some of the observed visual function impairments in PD subjects might be due to α-synucleinopathy.
Sponsor: This project was funded by the Michael J. Fox Foundation for Parkinson’s Research. Funding for the recruitment and clinical and neuropathological characterization of human subjects, as well as other operating costs of the Brain and Body Donation Program, have been partially supplied by the National Institute of Neurological Disorders and Stroke (U24 NS072026 National Brain and Tissue Resource for Parkinson’s Disease and Related Disorders), the National Institute on Aging (P30 AG19610 Arizona Alzheimer’s Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Research Center), the Arizona Biomedical Research Commission (contracts 4001, 0011, 05-901 and 1001 to the Arizona Parkinson’s Disease Consortium) and the Michael J. Fox Foundation for Parkinson’s Research.
ISSN: 0304-3940 (Print) | 1872-7972 (Online)
DOI: 10.1016/j.neulet.2014.04.027
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2014 Elsevier Ireland Ltd.
Peer Review: si
Publisher version:
Appears in Collections:INV - NEUROVIS - Artículos de Revistas

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