Modulation of the Silica Sol–Gel Composition for the Promotion of Direct Electron Transfer to Encapsulated Cytochrome c

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Title: Modulation of the Silica Sol–Gel Composition for the Promotion of Direct Electron Transfer to Encapsulated Cytochrome c
Authors: Gamero Quijano, Daniel Alonso | Huerta Arráez, Francisco | Morallon, Emilia | Montilla, Francisco
Research Group/s: Electrocatálisis y Electroquímica de Polímeros
Center, Department or Service: Universidad de Alicante. Departamento de Química Física | Universidad de Alicante. Instituto Universitario de Materiales
Keywords: Silica sol-gel composition | Direct electron transfer | Encapsulated cytochrome c
Knowledge Area: Química Física
Issue Date: 11-Aug-2014
Publisher: American Chemical Society
Citation: Langmuir. 2014, 30(34): 10531-10538. doi:10.1021/la5023517
Abstract: The direct electron transfer between indium–tin oxide electrodes (ITO) and cytochrome c encapsulated in different sol–gel silica networks was studied. Cyt c@silica modified electrodes were synthesized by a two-step encapsulation method mixing a phosphate buffer solution with dissolved cytochrome c and a silica sol prepared by the alcohol-free sol–gel route. These modified electrodes were characterized by cyclic voltammetry, UV–vis spectroscopy, and in situ UV–vis spectroelectrochemistry. The electrochemical response of encapsulated protein is influenced by the terminal groups of the silica pores. Cyt c does not present electrochemical response in conventional silica (hydroxyl terminated) or phenyl terminated silica. Direct electron transfer to encapsulated cytochrome c and ITO electrodes only takes place when the protein is encapsulated in methyl modified silica networks.
Sponsor: We also acknowledge the Financial support from the Spanish Ministerio de Economía y Competitividad and FEDER y Ciencia (MAT2010-15273), Generalitat Valenciana (PROMETEO2013/038), and the Fundación Ramón Areces (CIVP16A1821). Alonso Gamero-Quijano is grateful to Generalitat Valenciana (Santiago Grisolia Program) for the funding of his research fellowship.
URI: http://hdl.handle.net/10045/46336
ISSN: 0743-7463 (Print) | 1520-5827 (Online)
DOI: 10.1021/la5023517
Language: eng
Type: info:eu-repo/semantics/article
Rights: © 2014 American Chemical Society
Peer Review: si
Publisher version: http://dx.doi.org/10.1021/la5023517
Appears in Collections:INV - GEPE - Artículos de Revistas

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