Biscarboxy-Functionalized Imidazole and Palladium as Highly Active Catalytic System in Protic Solvents: Methanol and Water

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Title: Biscarboxy-Functionalized Imidazole and Palladium as Highly Active Catalytic System in Protic Solvents: Methanol and Water
Authors: Martínez Flores, Regina | Pastor, Isidro M. | Yus, Miguel
Research Group/s: Nuevos Materiales y Catalizadores (MATCAT) | Síntesis Asimétrica (SINTAS)
Center, Department or Service: Universidad de Alicante. Departamento de Química Orgánica | Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Keywords: Palladium | Organometallic reagents | Heterocycles | Solvent effects | Cross-coupling
Knowledge Area: Química Orgánica
Issue Date: 2014
Publisher: Georg Thieme Verlag
Citation: Synthesis. 2014, 46(21): 2965-2975. doi:10.1055/s-0034-1378552
Abstract: The coupling reaction between aryl bromides and boron reagents is efficiently catalyzed by an in situ generated palladium complex obtained from palladium(II) acetate (0.1 mol%) and 1,3-bis(carboxymethyl)imidazole (0.2 mol%). The catalytic system is very active in protic solvents, especially in methanol. Biaryl derivatives have been prepared in good isolated yields (up to >99%), and additionally styrene and stilbene derivatives have also been prepared by means of this protocol.
Sponsor: Financial support from the Ministerio de Ciencia e Innovación (MICINN) of Spain (Project Nos. CTQ2007-65218, CTQ2011-24165, Consolider Ingenio 2010 CSD2007-00006), the Generalitat Valenciana (PROMETEO/2009/039 and FEDER), and the Universidad de Alicante is acknowledged.
ISSN: 0039-7881 (Print) | 1437-210X (Online)
DOI: 10.1055/s-0034-1378552
Language: eng
Type: info:eu-repo/semantics/article
Rights: © Georg Thieme Verlag Stuttgart · New York
Peer Review: si
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Appears in Collections:INV - MATCAT - Artículos de Revistas
INV - SINTAS - Artículos de Revistas
INV - AMIC - Artículos de Revistas

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